Naoki Harada

TL;DR: Chk2 plays a critical role in p53 function in response to IR by regulating its transcriptional activity as well as its stability, suggesting the existence of an ATM/ATR‐dependent but Chk2‐independent pathway for p53 stabilization.

TL;DR: CH5126766 represents a new type of MEK inhibitor that causes MEK to become a dominant-negative inhibitor of RAF and that, in doing so, may have enhanced therapeutic activity in ERK-dependent tumors with mutant RAS.

TL;DR: Cloning a cDNA for human IgGFc binding protein (FcγBP) from human colonic epithelial cells reveals an mRNA and coding region of 17 and 16.2 kilobases, respectively, suggesting that Fcγ BP may play an important role in immune protection and inflammation in the intestines of primates.

TL;DR: The immunohistochemical study revealed that mucin secreting cells in the colon, small intestine, gall bladder, cystic duct, choledochus, bronchus, submandibular gland, and cervix uteri contained FcγBP, and immunodotblot and immunoprecipitation analysis using IgG and monoclonal antibodies demonstrated that the fluids secreted by these cells were capable of binding IgG.

TL;DR: In this article, a compound represented by general formula (1) below or a pharmaceutically acceptable salt thereof (2) is presented. But the present invention does not provide a pharmaceutical composition containing the compound or salt as an active ingredient.