M
Makoto Nakanishi
Researcher at University of Tokyo
Publications - 185
Citations - 10398
Makoto Nakanishi is an academic researcher from University of Tokyo. The author has contributed to research in topics: DNA damage & Cell cycle. The author has an hindex of 50, co-authored 176 publications receiving 9330 citations. Previous affiliations of Makoto Nakanishi include University of California, Berkeley & Gifu University.
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Journal ArticleDOI
Aberrant cell cycle checkpoint function and early embryonic death in Chk1 −/− mice
Hiroyuki Takai,Kaoru Tominaga,Noboru Motoyama,Yohji A. Minamishima,Hiroyasu Nagahama,Tadasuke Tsukiyama,Kyoji Ikeda,Keiko Nakayama,Makoto Nakanishi,Keiichi I. Nakayama +9 more
TL;DR: Targeted disruption of Chk1 in mice showed that ChK1(-/-) embryos exhibit gross morphologic abnormalities in nuclei as early as the blastocyst stage, which may indicate that Chk 1 is indispensable for cell proliferation and survival through maintaining the G(2) checkpoint in mammals.
Journal ArticleDOI
DNA damage checkpoints in mammals.
Hiroyuki Niida,Makoto Nakanishi +1 more
TL;DR: The genes involved in checkpoint signaling are classified into four categories, namely sensors, mediators, transducers and effectors, although their proteins have the broad activity, and thus this classification is for convenience and is not definitive.
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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription.
Hiroyuki Takai,Kazuhito Naka,Yuki Okada,Miho Watanabe,Naoki Harada,Shin'ichi Saito,Carl W. Anderson,Ettore Appella,Makoto Nakanishi,Hiroshi Suzuki,Kazuo Nagashima,Hirofumi Sawa,Kyoji Ikeda,Noboru Motoyama +13 more
TL;DR: Chk2 plays a critical role in p53 function in response to IR by regulating its transcriptional activity as well as its stability, suggesting the existence of an ATM/ATR‐dependent but Chk2‐independent pathway for p53 stabilization.
Journal ArticleDOI
CCAAT/enhancer-binding protein alpha (C/EBP alpha) inhibits cell proliferation through the p21 (WAF-1/CIP-1/SDI-1) protein.
TL;DR: Induction of p21/SDI-1 is responsible for the ability of C/EBPalpha to inhibit proliferation because transcription of antisense p21/(SDI)-1 mRNA eliminated growth inhibition by C/ EBPalpha.
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Eukaryotic DNA polymerases: proposal for a revised nomenclature.
Peter M. J. Burgers,Eugene V. Koonin,Elspeth A. Bruford,Luis Blanco,Kenneth C. Burtis,Michael F. Christman,William C. Copeland,Errol C. Friedberg,Fumio Hanaoka,David C. Hinkle,Christopher W. Lawrence,Makoto Nakanishi,Haruo Ohmori,Louise Prakash,Satya Prakash,Claude Agnes Reynaud,Akio Sugino,Takeshi Todo,Zhigang Wang,Jean Claude Weill,Roger Woodgate +20 more
TL;DR: This work presents a meta-anatomy of DNA replication and its role in disease and Immunity that has never been seen before in the clinic and shows clear patterns in the immune response to various types of viruses.