Naomoto Harada

TL;DR: Experimental genetic evidence is presented that activation of the Wnt signaling pathway can cause intestinal and colonic tumors.

TL;DR: Female Gpbar1 homozygous mice showed significant fat accumulation with body weight gain compared with that of the wild-type mice, indicating that Gp bar1 is a potential new player in energy homeostasis.

TL;DR: It is reported here that conditional stabilization of β-catenin in immature thymocytes resulted in the generation of single positive T cells that lacked the αβ TCR and developed in the absence of pre-TCR signaling and TCR selection.

TL;DR: It is reported that hepatocellular carcinoma develops at the 100% incidence in mice with simultaneous mutations in the β-catenin and H-ras genes that are introduced by adenovirus-mediated Cre expression, and that these mice provide a convenient model to investigate early steps of hepatocarcinogenesis.

TL;DR: A critical role for the Wnt/beta-catenin signal transduction pathway in the differentiation of the respiratory epithelium in the postnatal lung is demonstrated.