Showing papers by "Naseer Ahmed published in 2022"

Augmented Reality and Virtual Reality in Dentistry: Highlights from the Current Research

Abstract: Many modern advancements have taken place in dentistry that have exponentially impacted the progress and practice of dentistry. Augmented reality (AR) and virtual reality (VR) are becoming the trend in the practice of modern dentistry because of their impact on changing the patient’s experience. The use of AR and VR has been beneficial in different fields of science, but their use in dentistry is yet to be thoroughly explored, and conventional ways of dentistry are still practiced at large. Over the past few years, dental treatment has been significantly reshaped by technological advancements. In dentistry, the use of AR and VR systems has not become widespread, but their different uses should be explored. Therefore, the aim of this review was to provide an update on the contemporary knowledge, to report on the ongoing progress of AR and VR in various fields of dental medicine and education, and to identify the further research required to achieve their translation into clinical practice. A literature search was performed in PubMed, Scopus, Web of Science, and Google Scholar for articles in peer-reviewed English-language journals published in the last 10 years up to 31 March 2021, with the help of specific keywords related to AR and VR in various dental fields. Of the total of 101 articles found in the literature search, 68 abstracts were considered suitable and further evaluated, and consequently, 33 full-texts were identified. Finally, a total of 13 full-texts were excluded from further analysis, resulting in 20 articles for final inclusion. The overall number of studies included in this review was low; thus, at this point in time, scientifically-proven recommendations could not be stated. AR and VR have been found to be beneficial tools for clinical practice and for enhancing the learning experiences of students during their pre-clinical education and training sessions. Clinicians can use VR technology to show their patients the expected outcomes before the undergo dental procedures. Additionally, AR and VR can be implemented to overcome dental phobia, which is commonly experienced by pediatric patients. Future studies should focus on forming technological standards with high-quality data and developing scientifically-proven AR/VR gadgets for dental practice.

Advances in Solar PV Systems; A Comprehensive Review of PV Performance, Influencing Factors, and Mitigation Techniques

Abstract: PV power plants utilizing solar energy to generate electricity on a large scale has become a trend and a new option that has been adopted by many countries; however, in actuality, it is difficult to anticipate how much electricity PV plants will generate. This analysis of existing photovoltaic (PV) power plants provides guidelines for more precise designs and performance forecasting of other upcoming PV technologies. In the literature, some authors have put their efforts into reviewing studies on PV power systems; however, those reviews are too focused on specific aspects of the topic. This study will review, from a broader perspective, recent investigations on PV power systems in the literature that were published between 1990 and 2022. The present study is divided into three main parts. Firstly, a performance assessment review of PV power plants is presented by taking different performance parameters into consideration, which were developed by the “International Electrotechnical Commission (IEC 61724-1)”. These parameters include reference yield, final yield, performance ratio, capacity utilization factor, and system efficiency. Secondly, different identifying factors that were investigated in previous studies, and which affect PV performance, were considered. These factors include solar irradiance, PV technology type, ambient temperature, cell temperature, tilt angle, dust accumulation, and shading effect. Thirdly, different methods were adopted and suggested to counter the effects of these influencing factors to enhance the performance efficiency of the PV power system. A hybrid cooling and cleaning system can use active techniques to boost efficiency during high solar irradiances and ambient temperatures while depending on passive techniques for everyday operations. This comprehensive and critical review identifies the challenges and proposed solutions when using photovoltaic technologies and it will be helpful for researchers, designers, and investors dealing with PV power systems.

Effect of Erosive Agents on Surface Characteristics of Nano-Fluorapatite Ceramic: An In-Vitro Study

Abstract: Erosive beverages cause dissolution of natural teeth and intra-oral restorations, resulting in surface characteristic changes, particularly roughness and degradation. The purpose of this study was to evaluate the surface roughness and topography of a dental ceramic following immersion in locally available erosive solutions. A total of 160 disc specimens of a nano-fluorapatite type ceramic (12 mm diameter and 2 mm thickness) were fabricated and equally distributed into two groups (n = 80) and then evenly distributed among the following five testing groups (n = 16): lemon juice, citrate buffer solution, 4% acetic acid, soft cola drink, and distilled water which served as a control. The surface roughness (Ra) and topography were evaluated using a profilometer and scanning electron microscope at baseline, 24 h, 96 h, and 168 h respectively. Data were analyzed using ANOVA and Tukey’s multiple comparisons (p ≤ 0.05). Surface changes were observed upon exposure to all acidic beverages except distilled water. Amongst all immersion media, 4% acetic acid produced the most severe surface roughness across all time periods (i.e., baseline, 24 h, 96 h, and 168 h). A statistically significant difference in the surface roughness values between all immersion media and across all four time intervals was observed. Erosive agents had a negative effect on the surface roughness and topography of the tested ceramic. The surface roughness increased with increased storage time intervals.

An In-Vitro Evaluation of Microleakage in Resin-Based Restorative Materials at Different Time Intervals

Abstract: A vital feature of conservative dentistry is the adhesion of the restorative material to the tooth structure for restoration of the tooth substance lost due to dental decay, trauma, or dental imperfections. In a perfect world, a restorative material should generate a lasting adhesion by bonding the restoration with tooth tissues. The ingress of micro-organisms, oral fluids, molecules, and ions through microscopic spaces due to faulty adhesion between restoration and tooth structure is known as microleakage. This study is focuses on the evaluation of adhesive failures between the restorative materials. In the past, studies have focused more on the bonding potential of a restorative material with the tooth surface. Therefore, there is need to carry out a study that compares the microleakage between resin-based restorative materials in a sandwich manner with and without the intermediate bonding layer after immersion in 2% methylene blue dye at different time intervals. The restorative materials used were composite Ceram X Mono plus (DENTSPLY) and Z350 (3M ESPE), Vitremer resin modified glass ionomer cement (RMGIC) (3M ESPE), smart dentine replacement SDR (3M ESPE), Bond NT (DENTSPLY), and Universal Bond (3M ESPE). A light emitting diode (LED) was used to cure the specimens. Artificial saliva was used as a storage medium for the specimens. Thermocycling of specimens was carried out at 500 cycles/30 s and 1000 cycles/30 s. The world health organization (WHO) grading tool for microleakage was used to analyze fluid ingress in the specimens through disclosing by 2% methylene blue dye. The statistical analysis was carried out with one-way analysis of variance (ANOVA) and Tukey post hoc test, keeping the level of significance at p ≤ 0.05. In Grade 0 = 85 samples, Grade 1 = 10 samples, Grade 2 = 7 samples, Grade 3 = 16 samples, and in Grade 4 = 2 samples were identified. This study describes that no microleakage was observed in SDR and resin composite groups as compared to Vitremer and resin composite groups.

Influence of soaking and germination treatments on the nutritional, anti-nutritional, and bioactive composition of pigeon pea (Cajanus cajan L.)

Abstract: Pigeon pea ( Cajanus cajan L.) is an important perennial pulse from the family Fabaceae. It is one of the important underutilized pulses having high nutritional value and can be used as a basic ingredient for the preparation of value- added food products. The present investigation aimed to study the influence of soaking and germination on nutritional and anti-nutritional components, minerals (Fe, Zn, Mn, and Cu), and bioactive components of pigeon pea grains. The effect of soaking was studied at 12 and 24 h while that of germination at 24, 48, and 72 h. The results revealed that there was a 6.34% and 15.41% increase in protein contents during soaking and germination treatments, respectively. A significant ( P ≤ 0.05) increase in reducing power (91.46%) and metal chelating activity (64.16%) was observed in germinated pigeon pea. The phenolic components and antioxidant activity increased by 5.34 and 76.15% after 72 h of germination, respectively, but the anti-nutritional components like tannin contents and the phytic acids decreased significantly ( P ≤ 0.05) by 57.97 and 63.05%, respectively after 72 h of germination. A significant ( P ≤ 0.05) increase in mineral contents was observed after the soaking and germination treatments of pigeon pea grains. Therefore the soaking and germination processing of pigeon pea grains resulted in enhancing the nutritive value and bioactive potential with a reduction in anti-nutritional compounds.

The Effectiveness of Lasers in Treatment of Oral Mucocele in Pediatric Patients: A Systematic Review

Abstract: The mucocele is the most common minor salivary gland associated disease of the oral cavity. It is also considered one of the most common biopsied oral lesions in pediatric patients. In recent years, extensive evidence has been published about the usage of lasers in treating mucoceles in pediatric patients. The aim of the present study was to assess the effectiveness of laser irradiation in the treatment of pediatric mucocele. An electronic search of databases (PubMed, Scopus, Web of Science and Google Scholar) was carried out in order to identify all relevant articles using a combination of the following keywords: “Pediatric”, “Oral”, “Mucocele”, “Dental”, “Oral Medicine”, “Soft Dental Lasers”, “Hard Dental Lasers”, and “Lasers,” for all case reports, case series, case-control and cohort studies published from 2007 to 2021. After limiting the search results, removing duplicate titles, and eligibility evaluation, 17 papers were enrolled in the study. Out of the total studies included, 10 articles were related to the diode (635 nm, 808 nm, 810 nm, and 980 nm), 5 to CO2 (10,600 nm), 3 to Er, Cr: YSGG (2780 nm), and 1 involving KTP lasers (532 nm). All studies indicated successful clinical results on mucocele excision with better intra- and post-operative indicators. The general characteristics and outcomes were summarized, and the quality of the studies was assessed using CARE guidelines in this systematic review. The reduction or absence of pain and bleeding, hemostasis, reduced operating time, minimal analgesic consumption, and an antibacterial effect were among the advantages of laser irradiation in the included studies. The laser has proven itself to play an effective role in the treatment of oral mucocele in paediatric patients.

Impact of soaking, germination, fermentation, and roasting treatments on nutritional, anti-nutritional, and bioactive composition of black soybean (Glycine max L.)

Abstract: Legumes are plants of the family Leguminosae with seed pods that split into two halves. Black soybean seed coat contains numerous bioactive compounds having radical scavenging, anti-tumor, and anti-carcinogenic activities. This study was aimed to assess the effect of soaking, germination, natural fermentation, and roasting on nutritional and antinutritional components, minerals (Fe, Zn, Mn, and Cu), and bioactive components of the black soybean. The effect of soaking was studied at 12 and 24 h while that of germination at 24, 48, and 72 h. The results revealed that the phenolic contents augmented significantly ( P ≤ 0.05) in germination, fermentation, and roasting by 11.49%, 8.96%, 2.95%. Further, there was an 11.84% and 22.13% increase in the protein contents during the germination and fermentation processes, respectively. The antioxidant activity of processed grains increased significantly ( P ≤ 0.05) during germination, fermentation, and roasting by 72.51, 10.14, and 9.64%, respectively. The anti-nutritional compounds such as phytic acid and tannin contents decreased significantly ( P ≤ 0.05) during processing treatments. Phytic acid decreased to the extent of 34.04, 51.06, and 13.47% and tannin contents as 47.22, 75, and 38.89%, after germination, fermentation, and roasting processes, respectively. A significant ( P ≤ 0.05) increase in mineral contents was observed after the germination, fermentation, and roasting of the black soybean.

Assessment of the Current Endodontic Practices among General Dental Practitioners in the Kingdom of Saudi Arabia

Abstract: A contemporary knowledge of root canal treatment (RCT) is a prerequisite for a successful outcome. Studies observed that General Dental Practitioners (GDPs) were not abreast of current endodontic knowledge due to a lack of continuing dental education, not following the treatment protocols that they had learned in their undergraduate program, and overlooking the evidence-based current endodontic practices. Therefore, this study was intended to assess the awareness, attitude, and clinical endodontic practices among General Dental Practitioners in Saudi Arabia. This cross-sectional questionnaire-based study was conducted among all 312 GDPs working in Saudi Arabia. The questionnaire consisted of socio-demographic details and 23 questions regarding current endodontic practices. The collected data was analyzed using the SPSS Version 21 (Chicago, IL, USA). The chi-square test was applied to explore the influence of gender, workplace, and the years of professional activity on the materials and techniques employed in the RCT procedure. The study results showed that of all respondents, 159 (51.0%) were males, 153 (49.0%) were females, and 286 (91.7%) were Saudi nationals. Most of the GDPs, i.e., 204 (65.4%) practiced in private hospitals or clinics whereas 108 (34.6%) practiced in Government hospitals. Root canal treatment on all teeth had been performed by 196 (62%) of the practitioners. Association of gender with demographic details and endodontic practices revealed a statistically significant difference between both genders with respect to region, nationality, type of RCT treated on the tooth, and the technique used to measure the working length (p < 0.05). Furthermore, years of professional experience and workplace significantly affect endodontic practices (p < 0.05). This study concluded that most of the general dental practitioners complied with quality standard guidelines showing a positive attitude toward endodontic practices. Furthermore, irrespective of gender, most of the steps in endodontic procedures revealed a significant association with years of professional experience and the workplace.

A Comprehensive Review of Machine-Integrated Electric Vehicle Chargers

Abstract: Electric Vehicles are becoming increasingly popular due to their environment friendly operation. As the demand for electric vehicles increases, it has become quite important to explore their charging strategies. Since charging and traction do not normally occur simultaneously and the power electronics converters for both operations have some similarities, the practice of integrating both charging and traction systems is becoming popular. These types of chargers are termed ‘Integrated Chargers’. The aim of this paper is to review the available literature on the integrated chargers and present a critical analysis of the pros and cons of different integrated charging architectures. Integrated chargers for electric vehicles with three-phase permanent magnet synchronous machines, multi-phase machines and switched reluctance machines were compared. The challenges with the published integrated chargers and the future aspect of the work were been discussed.

An Analysis of Maxillary Anterior Teeth Crown Width-Height Ratios: A Photographic, Three-Dimensional, and Standardized Plaster Model's Study

Abstract: Objective To analyze the width and height ratios of maxillary anterior teeth at different crown levels through photographs, 3D, and plaster dental model techniques in a subset of the Pakistani population. Material and Methods. This clinical study consisted of 230 participants. The maxillary impression, standardized photographs, and models were constructed for crown width and height analysis. The SPSS version 25 was used for statistical analysis. Descriptive statistics were carried out for mean, standard deviation, and percentage calculation of teeth width and height, gender, and age of participants. Paired t-test analysis was carried out to compare the dependent variables (teeth size, width, and height ratios) with independent variables (techniques applied, side disparity). A p value of ≤ 0.05 was considered statistically significant. Results The mean width and height of maxillary anterior teeth obtained through photographs, 3D, and plater models were statistically different. The 3D dental model analysis showed reliable and accurate results. The mean width and height ratio of teeth were different on both sides of the arch. There was a significant difference (p = 0.001) in crown width-height ratios at different crown levels. Conclusion The width and height ratios in the studied population were different at various crown levels. The dimensions of teeth varied from the incisal to the cervical part of the crown. Hence, rather than relying on a single, fixed ratio of 78% to 80% suggested by researchers for anterior teeth, the clinician should adopt different crown width-height ratios to restore teeth with the optimum esthetic outcome.

Impact of Pre-Treatment NLR and Other Hematologic Biomarkers on the Outcomes of Early-Stage Non-Small-Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy

Abstract: Introduction: We evaluated the association of pre-treatment immunologic biomarkers on the outcomes of early-stage non-small-cell lung cancer (NSCLC) patients treated with stereotactic body radiation therapy (SBRT). Materials and methods: In this retrospective study, all newly diagnosed early-stage NSCLC treated with SBRT between January 2010 and December 2017 were screened and included for further analysis. The pre-treatment neutrophil-lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR), and platelet-lymphocyte ratio (PLR) were calculated. Overall survival (OS) and recurrence-free survival (RFS) were estimated by Kaplan–Meier. Multivariable models were constructed to determine the impact of different biomarkers and the Akaike information criterion (AIC), index of adequacy, and scaled Brier scores were calculated. Results: A total of 72 patients were identified and 61 were included in final analysis. The median neutrophil count at baseline was 5.4 × 109/L (IQR: 4.17–7.05 × 109/L). Median lymphocyte count was 1.63 × 109/L (IQR: 1.29–2.10 × 109/L), median monocyte count was 0.65 × 109/L (IQR: 0.54–0.83 × 109/L), median platelet count was 260.0 × 109/L (IQR: 211.0–302.0 × 109/L). The median NLR was 3.42 (IQR: 2.38–5.04), median MLR was 0.39 (IQR: 0.31–0.53), and median PLR was 156.4 (IQR: 117.2–197.5). On multivariable regression a higher NLR was associated with worse OS (p = 0.01; HR-1.26; 95% CI 1.04–1.53). The delta AIC between the two multivariable models was 3.4, suggesting a moderate impact of NLR on OS. On multivariable analysis, higher NLR was associated with poor RFS (p = 0.001; NLR^1 HR 0.36; 0.17–0.78; NLR^2 HR-1.16; 95% CI 1.06–1.26) with a nonlinear relationship. The delta AIC between the two multivariable models was 16.2, suggesting a strong impact of NLR on RFS. In our cohort, MLR and PLR were not associated with RFS or OS in multivariable models. Conclusions: Our study suggests NLR, as a biomarker of systemic inflammation, is an independent prognostic factor for OS and RFS. The nonlinear relationship with RFS may indicate a suitable immunological environment is needed for optimal SBRT action and tumoricidal mechanisms. These findings require further validation in independent cohorts.

A Comparative Study on Alvogyl and a Mixture of Black Seed Oil and Powder for Alveolar Osteitis: A Randomized Double-Blind Controlled Clinical Trial

Abstract: Introduction Alveolar osteitis (AO) is the most common complication faced by exodontia patients and is usually seen 24–74 hours after tooth extraction, heralded by severe throbbing pain. Nigella sativa is commonly known as black seed known to have anti-inflammatory and antibacterial properties along with other reparative properties that enhance bone formation. This study aimed to evaluate and compare the effects of Alvogyl and a mixture of Nigella sativa powder and oil in the treatment of dry sockets. Materials and Methods Sixty patients above the age of 18 and below 70 years, from both genders, who underwent extraction of teeth and were clinically diagnosed with a dry socket at the clinic of the College of Dentistry, Jouf University, Saudi Arabia, were included in this study. Pain scores were assessed after placement of the dressing at the following intervals: 5 minutes, 30 minutes, 60 minutes, 2nd day, 4th day, and 7th day. Patients were randomly allocated to three groups, namely, Group 1 (Alvogyl), Group 2 (mixture of Nigella sativa's powder and oil), and Group 3 (control). Pain relief and healing of the socket were compared between the three groups. The collected data were subjected to statistical analysis through Spearman's correlation test, independent t-test, ANOVA, and post hoc test. Results A mixture of Nigella sativa powder and oil showed a statistically significant difference in relieving pain compared to the Alvogyl group. A mixture of Nigella sativa's powder and oil required fewer dressings when compared to the Alvogyl group. Conclusion A mixture of Nigella sativa powder and oil is the more efficacious dressing material for the management of dry sockets compared to Alvogyl. It provides immediate and complete pain relief and fewer numbers of repeated visits.

Potato Starch as Affected by Varieties, Storage Treatments and Conditions of Tubers

Abstract: Potato is among the widely grown crop of the world. It is likely that a large portion of the crop is consumed fresh but majority of it is processed into various products, starch being the predominant one. Starch can greatly contribute to the textural properties of many foods and is widely used in food industry as raw material. Since raw potatoes are perishable and accessible only for few months of the year, the food and starch industry has to rely on stored potatoes during off-season. The various varieties of the crop available in the region, storage conditions, pre and post-storage treatments given to the tubers, packaging materials used, etc. are influencing the physical, chemical and functional characteristics of starch extracted from it. The extraction technology from tubers is also having a significant effect on the quality of starch. The knowledge of physical, chemical and functional characteristics of potato starch as affected by varieties, storage treatments and conditions of tubers will help in ensuring uniform and desirable quality of starch for food industry and also provide information for breeding programs and developing the proper postharvest management practices of potatoes.

Management of Edentulous Microstomia Patient: A Case Report and Classification System

Abstract: Microstomia is an abnormally reduced oral aperture. In the literature, it is not classified by any particular size criteria, rather defined by its effects on function and esthetics. Prosthodontic management of edentulous patients with microstomia is a challenging task. Use of conventional methods for recording an impression and fabricating prosthesis is not effective in such patients. To fabricate well-fitting prosthesis, accuracy of impression recording important anatomic landmarks is essential. Formation of an exacting custom tray and diagnostic cast is critical for final impression accuracy. Provision of a well-fitting prosthesis in microstomia patient will restore esthetics, comfort, and function with oral and systemic patient wellbeing. This paper presents a case report of managing an edentulous microstomia patient with sectional removable prosthesis. Furthermore, it proposes a novel classification system for microstomia patients according to severity of the condition.

Metabolic Alterations in Sputum and Exhaled Breath Condensate of Early Stage Non-Small Cell Lung Cancer Patients After Surgical Resection: A Pilot Study

Abstract: Every year, close to two million people world-wide are diagnosed with and die of lung cancer. Most patients present with advanced-stage cancer with limited curative options and poor prognosis. Diagnosis of lung cancer at an early stage provides the best chance for a cure. Low- dose CT screening of the chest in the high-risk population is the current standard of care for early detection of lung cancer. However, CT screening is invasive due to radiation exposure and carries the risk of unnecessary biopsies in non-cancerous tumors. In this pilot study, we present metabolic alterations observed in sputum and breath condensate of the same population of early- stage non-small cell lung cancer (NSCLC) patients cancer before and after surgical resection (SR), which could serve as noninvasive diagnostic tool. Exhaled breath condensate (EBC) (n=35) and sputum (n=15) were collected from early-stage non-small cell lung cancer (NSCLC) patients before and after SR. Median number of days for EBC and sputum collection before and after SR were 7 and 42; and 7 and 36 respectively Nuclear magnetic resonance (NMR) and liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) were used to analyze the metabolic profile of the collected samples. A total of 26 metabolites with significant alteration post SR were identified, of which 14 (54%) were lipids and 12 constituted nine different chemical metabolite classes. Eighteen metabolites (69%) were significantly upregulated and 8 (31%) were downregulated. Median fold change for all the up- and downregulated metabolites (LC-QTOF-MS) were 10 and 8, respectively. Median fold change (MFC) in concentration of all the up- and downregulated metabolites (NMR) were 0.04 and 0.27, respectively. Furthermore, glucose (median fold change, 0.01, p=0.037), adenosine monophosphate (13 log fold, p=0.0037) and N1, N12- diacetylspermine (8 log fold p=0.011) sputum levels were significantly increased post-SR. These identified sputa and EBC indices of altered metabolism could serve as basis for further exploration of biomarkers for early detection of lung cancer, treatment response, and targets for drug discovery. Validation of these promising results by larger clinical studies is warranted.

Nano-antivirals: A comprehensive review

Abstract: Nanoparticles can be used as inhibitory agents against various microorganisms, including bacteria, algae, archaea, fungi, and a huge class of viruses. The mechanism of action includes inhibiting the function of the cell membrane/stopping the synthesis of the cell membrane, disturbing the transduction of energy, producing toxic reactive oxygen species (ROS), and inhibiting or reducing RNA and DNA production. Various nanomaterials, including different metallic, silicon, and carbon-based nanomaterials and nanoarchitectures, have been successfully used against different viruses. Recent research strongly agrees that these nanoarchitecture-based virucidal materials (nano-antivirals) have shown activity in the solid state. Therefore, they are very useful in the development of several products, such as fabric and high-touch surfaces. This review thoroughly and critically identifies recently developed nano-antivirals and their products, nano-antiviral deposition methods on various substrates, and possible mechanisms of action. By considering the commercial viability of nano-antivirals, recommendations are made to develop scalable and sustainable nano-antiviral products with contact-killing properties. Graphical Abstract

Effect of diverse fermentation treatments on nutritional composition, bioactive components, and anti-nutritional factors of finger millet (Eleusine coracana L.)

Abstract: The finger millet (Eleusine coracana L.) flour was subjected to lactic acid fermentation using two strains of Lactobacillus, that is, with Lactobacillus brevis (BF) and Lactobacillus plantarum (PF), with yeast (Saccharomyces cerevisiae L.) (YF), and with yeast + ammonium sulfate used as fermentation activator (YAF) and combined treatment of yeast and L. brevis (CF) at an interval of 12, 24, and 36 h. The samples after drying were evaluated for their nutritional, antinutritional, minerals, and bioactive components. The total phenolic contents enhanced significantly (P ≤ 0.05) during all fermentation treatments but the highest values were observed after PF treatment. Similarly, there was a significant (P ≤ 0.05) enhancement in the antioxidant activity during all fermentation treatments, and the highest activity was observed during YAF treatment. Fermentation significantly (P ≤ 0.05) enhanced the crude proteins content but decreased the crude fiber and fat contents. A significant (P ≤ 0.05) increase in mineral content such as Cu, Fe, Mn, and Zn was observed after all fermentation treatments. Anti-nutrients such as phytic acid and tannins were reduced significantly (P ≤ 0.05) and the greatest reductions were observed during treatment with L. brevis (BF). Similarly, the tannin contents get reduced significantly (P ≤ 0.05) during all fermentation treatments. The present study, therefore, shows that fermentation could be the most effective method for improving the nutritional and bioactive components, as well as the antioxidant capacity of finger millet flour with a significant reduction in anti-nutritional components.

Non-extraction orthodontic treatment for severe dental crowding using miniscrew-assisted rapid maxillary expansion

Abstract: Abstract Malocclusion is caused by an incorrect relationship between the teeth and jaws, which leads to an abnormal variation of normal occlusion. Crowding is an increasingly common type of malocclusion caused by a discrepancy in tooth-jaw size that leads to twisted and misaligned teeth. Two methods to treat this malalignment are tooth material reduction and arch width expansion. Of these two treatment options, the latter is preferred because it enables orthodontists to avoid extractions and increase the dental arch perimeter by widening the jaws; this resolves crowding and accommodates existing teeth. This case report describes a unique approach in the treatment of a patient with severe crowding by an orthopaedic widening of the dental arches using a skeletally anchored rapid palatal expander. Under favorable circumstances, this approach can serve as a robust method to treat patients with severe crowding and may be used as an alternative to extraction.

The Analysis of Facio-Dental Proportions to Determine the Width of Maxillary Anterior Teeth: A Clinical Study

Abstract: The present study aimed to analyze mid horizontal facial third proportions, those being the interpupillary, inner intercanthal, and bizygomatic distance modified with golden proportion, The Preston proportion, golden percentage and 70% recurring esthetic dental proportion were used for determining maxillary anterior teeth width. A total of 230 participants took part in this study. The front dental and facial photographs along dental stone cast which were converted to three-dimensional (3D) models were used for evaluation. The mid horizontal facial third proportions showed no significant relationship with maxillary anterior teeth width without modification with dental proportions. Whereas, with modification, no statistically significant difference was found between inner-intercanthal distance by golden percentage and width of central incisors. The bizygomatic distance was greater than intercanine distance. While the interpupillary distance by golden proportion was found to be consistent with intercanine distance in female participants. The modified anterior teeth width was significantly different from measured values, when determined by using the three mid facial proportions with Preston and 70% recurring esthetic dental (RED) proportion. Furthermore, the measured width of maxillary anterior teeth showed no difference when plaster dental casts widths were compared with 3D models. The interpupillary, inner-intercanthal, and bizygomatic distance should not be directly used to determine maxillary anterior teeth width. While maxillary anterior teeth width can be determined by modifying the inner inter-canthal distance with golden percentage and interpupillary distance with golden proportion. Moreover, the midfacial third proportions modified with Preston and 70% recurrent esthetic dental proportion were found to be unreliable for the determination of maxillary anterior teeth widths.

Optimal Restoration Sequence of Parallel Power System Using Genetic Algorithm

Abstract: The restoration of power systems is emphasized in the modern electric power system (EPS) due to complex, interconnected networks, and natural catastrophic events. However, large-scale disruptions in the power system result in a partial or complete blackout. Such events have a low probability and high impact, causing significant regional socio-economic losses. Hence, the black start (BS) resource is needed to deliver the cranking power to restart the non-black start (NBS) units, energize the path, load, and restore the complete system with parallel restoration. This paper implemented a novel optimal restoration scheme to restore the power system after partial or complete blackout. A multi-objective genetic algorithm is used to solve each island’s optimal generation unit’s start-up sequence, priority start of critical load and restoring the maximum load in minimum restoration time using an optimal transmission path with a minimum number of switching actions. A case study based on the IEEE-39 benchmark system validates the effectiveness of the proposed algorithm.

Nutritional and bioactive characteristics of buckwheat, and its potential for developing gluten‐free products: An updated overview

Abstract: Abstract In the present era, food scientists are concerned about exploiting functional crops with nutraceutical properties. Buckwheat is one of the functional pseudocereals with nutraceutical components used in the treatment of health‐related diseases, malnutrition, and celiac diseases. As a preferred diet as a gluten‐free product for celiac diseases, buckwheat is a good source of nutrients, bioactive components, phytochemicals, and antioxidants. The general characteristics and better nutritional profile of buckwheat than other cereal family crops were highlighted by previous investigations. In buckwheats, bioactive components like peptides, flavonoids, phenolic acids, d‐fagomine, fagopyritols, and fagopyrins are posing significant health benefits. This study highlights the current knowledge about buckwheat and its characteristics, nutritional constituents, bioactive components, and their potential for developing gluten‐free products to target celiac people (1.4% of the world population) and other health‐related diseases.

Genetic variation and population structure analysis of Leymus chinensis (Trin.) Tzvelev from Eurasian steppes using SSR makers

Abstract: Abstract Leymus chinensis (Trin.) Tzvelev is an important perennial grass species extensively dispersed in the typical grassland communities of the Eurasian steppe region. It is relished by livestock due to its high quality and being a nutritionally valuable forage crop. L. chinensis has recently gained extensive consideration on its genetic diversity. However, genetic diversity studies on L. chinensis using SSR markers is currently limited. In the present study, we investigate the genetic variation and population structure analysis of L. chinensis from Eurasian steppes using SSR makers. For the genetic diversity, nineteen SSR markers were used and a total of 133 alleles were identified across the 166 L. chinensis plants. Our findings illustrated that the polymorphic rate for all SSR markers was greater than 80%, with the exception of SSR12i and SSR6c, which had polymorphism rates of 50% and 75%, respectively. The gene diversity (H) ranged from 0.0545 for SSR12i to 0.4720 for SSR25v, and the average was 0.3136. Furthermore, genetic diversity analysis indicated that the 166 samples could be grouped into five main population clusters based on their maximum membership coefficients which were assigned as Pop1 to Pop5. Among the five populations, the largest values of allele (total number of detected alleles), Ne (effective number of alleles) and Na (observed mean number of alleles) was found to be higher in Pop1, with values of 61, 1.461, and 1.977, respectively. Additionally, AMOVA showed that 13% of the total genetic variation occurred among the population and 87% genetic variation within the populations of the species. Whereas, the pairwise Fst specified the moderate genetic variation ranging from 0.0336 to 0.0731. Finally, the principal coordinate analysis revealed that the x-axis and y-axis explained 5.72% and 4.86% of the variation in molecular data, respectively. Taken together, these SSR markers provide new insights for a more precise understanding of the genetic diversity of L. chinensis germplasm and could potentially enhance the breeding program of L. chinensis.

Hypokalemic Periodic Paralysis: An Atypical Presentation of Non-autoimmune Hypothyroidism With Distal Renal Tubular Acidosis

Abstract: Hypokalemic periodic paralysis (hypo KPP) is a rare form of autosomal dominant channelopathy characterized by muscular weakness and paralysis caused by decreased potassium levels. Precipitating factors are a diet rich in starches and sweets, and rest after an unusual degree of exercise. Paralytic attacks are more common between the ages of 15 and 40 years. The presentation can be a total paralysis or severe quadriplegia or mild weakness in certain group of muscles. During the acute episode of weakness proximal muscles are involved initially with gradual spread to the distal muscles. Deep reflexes are decreased or absent but the cognitive functions and sensory systems are intact. The paralysis may last for few hours to several days, but recovery is usually sudden in most patients. Hypo KPP is usually associated with thyroid disorders and distal renal tubular acidosis (DRTA). Here we report a case of young female patient who presented in emergency with two days history of weakness of all four limbs. The patient also had two episodes of similar illness in the last two and half years. On examination she had decreased tone and power in all four limbs with absent deep tendon reflexes, and plantar reflexes were down going bilaterally. On initial laboratory workup, patient was diagnosed to have hypokalemic, hyperchloremic metabolic acidosis with alkaline urine secondary to hypothyroidism. Features of hypokalemia with metabolic acidosis and failure to acidify urine was consistent with DRTA. Intravenous potassium chloride and bicarbonate replacement resulted in biochemical and clinical improvement.

Analysis of recurrent esthetic dental proportion of natural maxillary anterior teeth: A systematic review.

Abstract: The recurrent esthetic dental (RED) proportion has been a benchmark for the rehabilitation of the maxillary anterior teeth of North American patients. While it has been evaluated in other populations, the global application of RED proportions in the rehabilitation of maxillary anterior teeth is unclear.The purpose of this systematic review was to examine the existing evidence on dental proportion to evaluate the existence of RED proportions in the esthetic smile in different geographic regions.A systematic search was conducted by reviewing different databases. The focused question was "Does RED proportion exist in esthetically pleasing smiles in different populations around the world?" The search included articles with a combination of MeSH keywords based on dental proportion from January 2000 to July 2020. The titles and abstracts were identified by using a search protocol. Full text of the articles was independently evaluated. The systematic review was modified to summarize the relevant data. The general characteristics, outcomes, and quality of studies were reviewed and analyzed systematically.Seventeen studies were selected from the reviewed articles. Three studies were conducted in Europe, 10 in South Asia, and 4 in Western Asia. Eleven studies found that the mean perceived ratio of anterior teeth was not constant when progressing distally. Five studies reported that the ratio was constant in a small percentage of their populations, and 1 suggested that the ratio was constant if it remains between 60% and 80%. The central-to-LI and Ca-to-LI proportion values were not constant. Overall, the Ca-to-LI proportion values were higher than the central-to-LI proportions.RED proportions were not found in the successive widths of maxillary anterior teeth among the reviewed data from different geographic regions. RED proportions are not the only standard for restoring esthetic smiles worldwide, and anterior tooth proportions differ among populations based on their race and ethnicity.

Correlation of Red Blood Cell Distribution Width with The Severity of Coronary Artery Disease

Abstract: Atherosclerosis causing occlusion of coronary vessels by building up of plaque leading to narrowing of vessels supplying heart and causing coronary artery disease, which is the leading and common cause of mortality around the globe. Objective: To find the correlation of Red Cell Distribution Width (RDW) and severity of Coronary Artery Disease (CAD) lesions Methods: A number of 280 patients in total, admitted to cardiology department who presented with chest pain and diagnosed as angina, positive treadmill test and who underwent angiography and were found to have CAD, were enrolled in the study over a period of one year. Modified Gensini score (MGS) is used for assessment of severity of CAD. Each patient was assessed in relation to severity of CAD using MGS scoring system. Results: Out of 280 patients, 218 were assigned to Group A and 70 were assigned to Group B. Mean age of presentation were (52.34± 13.90 vs 50.8± 11.63 years). Male subjects were predominant overall with ratio of 2.63:1. RDW was assessed and was seen to be significantly elevated in Group A in comparison to Group B (14.98± 1.59 vs 13.82 ± 0.91p= <0.0001). After assessing MGS in relation to severity of CAD, significant correlation was observed. RDW was found to be increasing as MGS score increased (14.46± 0.65 vs 14.98± 1.00 vs 15.02± 0.88, p= <0.0001) Conclusions: It was concluded that RDW is a parameter which is cost effective, very easy, readily and urgently available for the assessment and stratification of patients presenting with coronary artery disease.

Analysis of Lower Facial Third and Dental Proportions to Predict Maxillary Anterior Teeth Width in the Pakistani Population

Abstract: Obtaining the size of the maxillary anterior teeth when performing an esthetic smile rehabilitation can be a difficult task. Metrics based on dental proportions to assist in the process are required. This study aimed to evaluate the lower facial third proportions i.e., the interalar, interphiltral, and intercommisural distance with dental proportions in predicting maxillary anterior teeth width in Pakistani citizens. This analytical study was conducted on 230 participants. Front face and retracted smile photographs were captured for all the participants, followed by maxillary impression making. The cast was then converted to 3D models for analysis. The data were entered into SPSS-25. Descriptive statistics were carried out for frequency, mean, standard deviation, and percentage calculation of gender, teeth widths, horizontal mid facial proportions, and age of the participants. Independent t-test was applied for analysis of gender and arch side disparity. Regression analyses were performed to analyze the relationship between independent variables (gender, age, weight, and height) and dependent variables (horizontal facial proportion, dental proportion). A p-value of ≤0.05 was considered statistically significant. The interphiltral distance (IPLD) modified with Preston proportion (PRP) showed no significant difference with combined central incisor width, whereas a significant difference was found with golden proportion (GP), 70% recurrent esthetic dental (RED) proportion, and golden percentage (GM) modification. However, the interalar (IAD) and intercommisural distance (ICoD) modified with dental proportions showed a significant difference with maxillary anterior teeth width. The width of maxillary anterior teeth determined by plaster dental cast and 3D dental cast showed no significant difference. The ICoD, IAD, and IPLD could not be used to determine combined central incisor and intercanine width directly. The interphiltral distance modified with Preston proportion is a reliable method to predict combined central incisor width in the population studied. There was a significant difference in gender disparity when ICD, IAD, and IPLD were modified with dental proportions, except in the case of IPLD by the Preston proportion group. The golden proportion, 70% RED proportion, and golden percentage by lower facial third facial proportions are not reliable methods to predict maxillary anterior teeth width.