Nathalie Baran

TL;DR: The observation that overexpression of STAT3 dominant-negative mutants abrogates this LIF responsiveness, clearly indicates that STAT3 is involved in LIF-regulated transcriptional events in ES cells, and suggests thatSTAT3 is a critical target of the LIF signaling pathway, which maintains pluripotent cell proliferation.

TL;DR: The model establishes the PRL receptor as a key regulator of reproduction and provides novel insights into the function of lactogenic hormones and their receptor.

TL;DR: It is demonstrated that the ovulation rate is not different between PRLR+/+ and PRLR-/- mice, and an elevated level of apoptosis and extensive inhibition of angiogenesis occur during the luteal transition in the absence of prolactin signaling.

TL;DR: Disruption of the PRLR gene has provided a new mouse model with which to identify actions directly associated with PRL or any other PRLR ligands, such as placental lactogens, and this model is being used to qualitatively and quantitatively evaluate the expression pattern of hepatic genes in two physiological situations.