Nathanael Lampe

TL;DR: This Special Report presents a description of Geant4-DNA user applications dedicated to the simulation of track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path…) and shows that the most recent sets of physics models available in Geant 4-DNA enable more accurate simulation of stopping powers, dose point kernels, and W-values in liquidWater.

TL;DR: The modelling of scavenging can play an important role in determining results, and it is speculated that high-scavenging regimes, where only chemical radicals within 1 nm of DNA are simulated, could provide a good means of testing mechanistic DNA simulations.

TL;DR: A generic Geant4 application for mechanistic DNA damage simulations to an Escherichia coli cell geometry is extended, finding electron damage yields and proton damage yields largely in line with experimental results.

TL;DR: A new alternative set of elastic and inelastic cross sections has been added to the very low energy extension of the Geant 4 Monte Carlo simulation toolkit, Geant4-DNA, for the simulation of electron interactions in liquid water.

TL;DR: Improved physics models for gold are necessary to better model the impact of GNPs in radiotherapy via Monte Carlo simulations, including the modeling of the full atomic de-excitation cascade.