J
Junya Toguchida
Researcher at Kyoto University
Publications - 219
Citations - 9881
Junya Toguchida is an academic researcher from Kyoto University. The author has contributed to research in topics: Mesenchymal stem cell & Gene. The author has an hindex of 51, co-authored 206 publications receiving 8992 citations. Previous affiliations of Junya Toguchida include University of Tokyo & Pharmaceuticals and Medical Devices Agency.
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Journal Article
Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene.
Toshiyuki Sakai,Junya Toguchida,Naoko Ohtani,David W. Yandell,Joyce M. Rapaport,Thaddeus P. Dryja +5 more
TL;DR: It is believed that the hypermethylation of the retinoblastoma gene that is found in these tumors corresponds to the allelic inactivation of the gene, and it is speculated that erroneous hyperethylation without alteration of nucleotide sequence occasionally plays a role in the genesis of this cancer.
Journal Article
Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.
Junya Toguchida,Toshikazu Yamaguchi,Bruce Ritchie,Roberta L. Beauchamp,Siri H. Dayton,Guillermo E. Herrera,Takao Yamamuro,Yoshihiko Kotoura,Masao S. Sasaki,John B. Little,Ralph R. Weichselbaum,Kanji Ishizaki,David W. Yandell +12 more
TL;DR: It is found that mutations of the p53 gene in sarcomas are quite heterogeneous both in their distribution throughout the gene and in the type of genetic alterations that result.
Journal ArticleDOI
Prevalence and Spectrum of Germline Mutations of the p53 Gene among Patients with Sarcoma
Junya Toguchida,Toshikazu Yamaguchi,Siri H. Dayton,Roberta L. Beaughamp,Guillermo E. Herrera,Kanji Ishizaki,Takao Yamamuro,Paul A. Meyers,John B. Little,Masao S. Sasaki,Ralph R. Weichselbaum,Ralph R. Weichselbaum,David W. Yandell +12 more
TL;DR: It appears that the group of patients with cancer who carry germline mutations of the p53 gene is more diverse than is suggested by the clinical definition of the Li-Fraumeni syndrome, and the identification of carriers could be of substantial clinical importance.
Journal ArticleDOI
Donor-dependent variations in hepatic differentiation from human-induced pluripotent stem cells
Masatoshi Kajiwara,Takashi Aoi,Keisuke Okita,Ryosuke Takahashi,Haruhisa Inoue,Naoya Takayama,Hiroshi Endo,Koji Eto,Junya Toguchida,Shinji Uemoto,Shinya Yamanaka +10 more
TL;DR: An improved hepatic differentiation protocol was developed and compared 28 hiPSC lines originated from various somatic cells and derived using retroviruses, Sendai viruses, or episomal plasmids and found that variations in hepatic differentiate were largely attributable to donor differences, rather than to the types of the original cells.
Journal ArticleDOI
Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells.
Takeshi Okamoto,Tomoki Aoyama,Tomitaka Nakayama,Takeharu Nakamata,Taisuke Hosaka,Koichi Nishijo,Takashi Nakamura,Tohru Kiyono,Junya Toguchida +8 more
TL;DR: These cell lines, being the first established immortalized clonal cell lines of hMSCs, could provide insights into the mechanisms regulating the early steps of differentiation from undifferentiated MSCs into a specific lineage.