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Neal Roehm
Researcher at Anschutz Medical Campus
Publications - 24
Citations - 3782
Neal Roehm is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: T cell & T-cell receptor. The author has an hindex of 14, co-authored 24 publications receiving 3765 citations. Previous affiliations of Neal Roehm include Jewish Hospital.
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Journal ArticleDOI
T cell tolerance by clonal elimination in the thymus
TL;DR: The results show that in normal animals tolerance to self-MHC is due to clonal elimination rather than suppression, and indicate that tolerance induction may occur in the thymus at the time immature thymocytes are selected to move into the mature thymocyte pool.
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A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product
John W. Kappler,Terri Wade,Janice White,E Kushnir,Marcia A. Blackman,Jerome Bill,Neal Roehm,Philippa Marrack +7 more
TL;DR: A bias in the germ-line T cell receptor repertoire toward recognition of MHC proteins is suggested and it is indicated that the V beta portion of the receptor may form the most important contact points with MHC ligands.
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The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.
Kathryn Haskins,Hannum Charles H,Janice White,Neal Roehm,Ralph T. Kubo,John W. Kappler,Philippa Marrack +6 more
TL;DR: Results suggest that KJ16-133 is directed against an allelic determinant on T cells that may be close to the membrane, and not in the receptor binding site for antigen plus MHC.
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Interleukin-induced increase in Ia expression by normal mouse B cells.
TL;DR: The results suggest that functional receptors for at least some interleukins are expressed on normal resting B cells and their effects can be manifest in the absence of additional activating signals, as shown in P388D1 and FS6-14.
Journal ArticleDOI
The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells☆
Neal Roehm,Lynne Herron,John C. Cambier,David Diguisto,Kathryn Haskins,John W. Kappler,Philippa Marrack +6 more
TL;DR: Results showed that Ag/MHC receptors are present on the surfaces of immature thymocytes, albeit at variable levels, during the time that the repertoire of these cells for Ag/ MHC is thought to be selected.