M
Marc J. Semigran
Researcher at Harvard University
Publications - 188
Citations - 18323
Marc J. Semigran is an academic researcher from Harvard University. The author has contributed to research in topics: Heart failure & Ejection fraction. The author has an hindex of 57, co-authored 187 publications receiving 16237 citations. Previous affiliations of Marc J. Semigran include Duke University & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
Apoptosis in Myocytes in End-Stage Heart Failure
Jagat Narula,Neena B. Haider,Renu Virmani,Thomas G. DiSalvo,Frank D. Kolodgie,Roger J. Hajjar,U Schmidt,Marc J. Semigran,G W Dec,Ban-An Khaw +9 more
TL;DR: Loss of myocytes due to apoptosis occurs in patients with end-stage cardiomyopathy and may contribute to progressive myocardial dysfunction.
Journal ArticleDOI
Diuretic Strategies in Patients with Acute Decompensated Heart Failure
G. Michael Felker,Kerry L. Lee,David A. Bull,Margaret M. Redfield,Lynne W. Stevenson,Steven R. Goldsmith,Martin M. LeWinter,Anita Deswal,Jean L. Rouleau,Elizabeth Ofili,Kevin J. Anstrom,Adrian F. Hernandez,Steven McNulty,Eric J. Velazquez,Abdallah G. Kfoury,Horng H. Chen,Michael M. Givertz,Marc J. Semigran,Bradley A. Bart,Alice M. Mascette,Eugene Braunwald,Christopher M. O'Connor +21 more
TL;DR: Among patients with acute decompensated heart failure, there were no significant differences in patients' global assessment of symptoms or in the change in renal function when diuretic therapy was administered by bolus as compared with continuous infusion or at a high dose asCompared with a low dose.
Journal ArticleDOI
The 2016 International Society for Heart Lung Transplantation listing criteria for heart transplantation: A 10-year update
Mandeep R. Mehra,Charles E. Canter,Margaret M. Hannan,Marc J. Semigran,Patricia A. Uber,David A. Baran,Lara Danziger-Isakov,James K. Kirklin,Richard Kirk,Sudhir S. Kushwaha,Lars Lund,Luciano Potena,Heather J. Ross,David O. Taylor,Erik A M Verschuuren,Andreas Zuckermann +15 more
TL;DR: The ISHLT Infectious Diseases, Pediatric and Heart Failure and Transplantation Councils Councils, and on behalf of the International Society for Heart Lung Trans transplantation (ISHLT) Infectious diseases, pediatric and heart failure and transplantation councilss are represented.
Journal ArticleDOI
Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: A randomized clinical trial
Margaret M. Redfield,Horng H. Chen,Barry A. Borlaug,Marc J. Semigran,Kerry L. Lee,Gregory D. Lewis,Martin M. LeWinter,Jean L. Rouleau,David A. Bull,Douglas L. Mann,Anita Deswal,Lynne W. Stevenson,Michael M. Givertz Elizabeth O Ofili,Michael M. Givertz Elizabeth O Ofili,Christopher M. O'Connor,G. Michael Felker,Steven R. Goldsmith,Bradley A. Bart,Steven McNulty,Jenny C. Ibarra,Grace Lin,Jae K. Oh,Manesh R. Patel,Raymond J. Kim,Russell P. Tracy,Eric J. Velazquez,Kevin J. Anstrom,Adrian F. Hernandez,Alice M. Mascette,Eugene Braunwald +29 more
TL;DR: Among patients with HFPEF, phosphodiesterase-5 inhibition with administration of sildenafil for 24 weeks, compared with placebo, did not result in significant improvement in exercise capacity or clinical status.
Journal ArticleDOI
Ultrafiltration in decompensated heart failure with cardiorenal syndrome
Bradley A. Bart,Steven R. Goldsmith,Kerry L. Lee,Michael M. Givertz,Christopher M. O'Connor,David A. Bull,Margaret M. Redfield,Anita Deswal,Jean L. Rouleau,Martin M. LeWinter,Elizabeth Ofili,Lynne W. Stevenson,Marc J. Semigran,G. Michael Felker,Horng H. Chen,Adrian F. Hernandez,Kevin J. Anstrom,Steven McNulty,Eric J. Velazquez,Jenny C. Ibarra,Alice M. Mascette,Eugene Braunwald +21 more
TL;DR: In a randomized trial involving patients hospitalized for acute decompensated heart failure, worsened renal function, and persistent congestion, the use of a stepped pharmacologic-therapy algorithm was superior to a strategy of ultrafiltration for the preservation of renal function at 96 hours, with a similar amount of weight loss with the two approaches.