A
Adrienne K. Chan
Researcher at Sunnybrook Health Sciences Centre
Publications - 129
Citations - 4589
Adrienne K. Chan is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 26, co-authored 110 publications receiving 3612 citations. Previous affiliations of Adrienne K. Chan include Sunnybrook Research Institute & University of Toronto.
Papers
More filters
Journal ArticleDOI
Identification of Severe Acute Respiratory Syndrome in Canada
Susan M. Poutanen,Susan M. Poutanen,Donald E. Low,Bonnie Henry,Sandy Finkelstein,David Rose,Karen Green,Raymond Tellier,Raymond Tellier,Ryan Draker,Dena Adachi,Melissa Ayers,Adrienne K. Chan,Danuta M. Skowronski,Irving E. Salit,Andrew E. Simor,Arthur S. Slutsky,Patrick Doyle,Mel Krajden,Martin Petric,Robert C. Brunham,Allison McGeer +21 more
TL;DR: SARS appears to be of viral origin, with patterns suggesting droplet or contact transmission, and the role of human metapneumovirus, a novel coronavirus, or both requires further investigation.
Journal Article
Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines.
TL;DR: The coexpression of certain costimulatory molecules and/or cytokines, in concert with a non-self gene delivered as an intramuscular plasmid DNA immunogen, can significantly enhance Ag-specific CTL responses.
Journal ArticleDOI
Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa
Síle F. Molloy,Cecilia Kanyama,Robert S. Heyderman,Angela Loyse,Charles Kouanfack,Duncan Chanda,Sayoki Mfinanga,Elvis Temfack,Shabir Lakhi,Sokoine Lesikari,Adrienne K. Chan,Neil Stone,Newton Kalata,Natasha Karunaharan,Katherine M Gaskell,Mary Peirse,Jayne Ellis,Chimwemwe Chawinga,Sandrine Lontsi,Jean-Gilbert Ndong,Philip Bright,Duncan Lupiya,Tao Chen,John S. Bradley,Jack Adams,Charles van der Horst,Joep J. van Oosterhout,Victor Sini,Yacouba Mapoure,Peter Mwaba,Tihana Bicanic,David G. Lalloo,Duolao Wang,Mina C. Hosseinipour,Olivier Lortholary,Shabbar Jaffar,Tom Harrison +36 more
TL;DR: Two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widely used fluconazole monotherapy were tested.
Journal ArticleDOI
Adjunctive Dexamethasone in HIV-Associated Cryptococcal Meningitis
Justin Beardsley,Marcel Wolbers,Freddie Kibengo,A.-B.M. Ggayi,A. Kamali,Ngo Thi Kim Cuc,Tran Quang Binh,N.V.V. Chau,Jeremy Farrar,Laura Merson,Lan Phuong,Guy E. Thwaites,N. Van Kinh,Pham Thi Thu Thuy,Wirongrong Chierakul,S. Siriboon,E. Thiansukhon,S. Onsanit,W. Supphamongkholchaikul,Adrienne K. Chan,Robert S. Heyderman,Edson Mwinjiwa,J.J. van Oosterhout,Darma Imran,Hasan Basri,Mayfong Mayxay,David A. B. Dance,P. Phimmasone,Sayaphet Rattanavong,David G. Lalloo,Jeremy N. Day +30 more
TL;DR: Dexamethasone did not reduce mortality among patients with HIV-associated cryptococcal meningitis and was associated with more adverse events and disability than was placebo and combination antifungal therapy with amphotericin B and fluconazole.
Journal ArticleDOI
Illness in Intensive Care Staff after Brief Exposure to Severe Acute Respiratory Syndrome
Damon C. Scales,Karen Green,Adrienne K. Chan,Susan M. Poutanen,Donna Foster,Kylie Nowak,Janet Raboud,Refik Saskin,Stephen E. Lapinsky,Thomas E. Stewart +9 more
TL;DR: The experience with a large number of healthcare workers who were exposed to a patient in an intensive-care unit (ICU) with undiagnosed SARS is described.