N
Nele Coeck
Researcher at Institute of Tropical Medicine Antwerp
Publications - 10
Citations - 760
Nele Coeck is an academic researcher from Institute of Tropical Medicine Antwerp. The author has contributed to research in topics: Mycobacterium tuberculosis & Bedaquiline. The author has an hindex of 7, co-authored 9 publications receiving 598 citations.
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Journal ArticleDOI
Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline
Koen Andries,Cristina Villellas,Nele Coeck,Kim Thys,Tom Gevers,Luc Vranckx,Nacer Lounis,Bouke C. de Jong,Anil Koul +8 more
TL;DR: It is reported that non-target based resistance to BDQ, and cross-resistance to clofazimine (CFZ), is due to mutations in Rv0678, a transcriptional repressor of the genes encoding the MmpS5-MmpL5 efflux pump.
Journal ArticleDOI
Unexpected high prevalence of resistance-associated Rv0678 variants in MDR-TB patients without documented prior use of clofazimine or bedaquiline.
Cristina Villellas,Nele Coeck,Conor J. Meehan,Nacer Lounis,Bouke C. de Jong,Leen Rigouts,Koen Andries +6 more
TL;DR: RAVs in Rv0678 occur more frequently in MDR-TB patients than previously anticipated, are not associated with prior use of bedaquiline or clofazimine, and in the majority of cases do not lead to bedquiline MICs above the provisional breakpoint.
Journal ArticleDOI
Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
Jody Phelan,Francesc Coll,Ruth McNerney,Ruth McNerney,David B. Ascher,Douglas E. V. Pires,Nicholas Furnham,Nele Coeck,Grant A. Hill-Cawthorne,Mridul Nair,Kim Mallard,Andrew Ramsay,Susana Campino,Martin L. Hibberd,Arnab Pain,Leen Rigouts,Taane G. Clark +16 more
TL;DR: Using the TDR resource, the usefulness of whole genome association and convergent evolution approaches to detect known and potentially novel mutations associated with drug resistance are demonstrated and could ultimately lead to novel resistance mutations.
Journal ArticleDOI
Specific gyrA gene mutations predict poor treatment outcome in MDR-TB
Leen Rigouts,Leen Rigouts,Nele Coeck,M Gumusboga,W B de Rijk,K. J. M. Aung,M A Hossain,K Fissette,Hans L. Rieder,Conor J. Meehan,B. C. de Jong,A. Van Deun +11 more
TL;DR: This study suggests that gyrA mutations at position 94, other than Ala, predict high-level resistance to gatifloxacin and moxiflOxacin, as well as poor treatment outcome, in MDR-TB patients in whom an injectable agent is still effective.
Additional file 1: Table S1. of Mycobacterium tuberculosis whole genome sequencing and protein structure modelling provides insights into anti-tuberculosis drug resistance
Jody Phelan,Francesc Coll,Ruth McNerney,David B. Ascher,Douglas Pires,Nicholas Furnham,Nele Coeck,Grant A. Hill-Cawthorne,Mridul Nair,Kim Mallard,Andrew Ramsay,Susana Campino,Martin L. Hibberd,Arnab Pain,Leen Rigouts,Taane G. Clark +15 more