R
Ruth McNerney
Researcher at University of Cape Town
Publications - 120
Citations - 7810
Ruth McNerney is an academic researcher from University of Cape Town. The author has contributed to research in topics: Tuberculosis & Mycobacterium tuberculosis. The author has an hindex of 48, co-authored 120 publications receiving 6598 citations. Previous affiliations of Ruth McNerney include University of London.
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Journal ArticleDOI
A robust SNP barcode for typing Mycobacterium tuberculosis complex strains.
Francesc Coll,Ruth McNerney,José Afonso Guerra-Assunção,Judith R. Glynn,João Perdigão,Miguel Viveiros,Isabel Portugal,Arnab Pain,Nigel Martin,Taane G. Clark +9 more
TL;DR: This SNP-based barcode is the first to cover all main lineages, and classifies a greater number of sublineages than current alternatives, and may be used to classify clinical isolates to evaluate tools to control the disease.
Journal ArticleDOI
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Keertan Dheda,Tawanda Gumbo,Gary Maartens,Kelly E. Dooley,Ruth McNerney,Megan Murray,Jennifer Furin,Edward A. Nardell,Leslie London,Erica Lessem,Grant Theron,Paul D. van Helden,Stefan Niemann,Matthias Merker,David W. Dowdy,Annelies Van Rie,Annelies Van Rie,Gilman Kit Hang Siu,Jotam G. Pasipanodya,Camilla Rodrigues,Taane G. Clark,F. A. Sirgel,Aliasgar Esmail,Hsien-Ho Lin,Sachin R Atre,H. Simon Schaaf,Kwok Chiu Chang,Christoph Lange,Payam Nahid,Zarir F Udwadia,C. Robert Horsburgh,Gavin J. Churchyard,Gavin J. Churchyard,Dick Menzies,Anneke C. Hesseling,Eric L. Nuermberger,Helen McIlleron,Kevin P. Fennelly,Eric Goemaere,Ernesto Jaramillo,Marcus Low,Carolina Morán Jara,Nesri Padayatchi,Robin M. Warren +43 more
TL;DR: Several lines of evidence suggest that alternative mechanisms-including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial to the pathogenesis of drug-resistant tuberculosis.
Journal ArticleDOI
Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test
Stephen D. Lawn,Peter Mwaba,Peter Mwaba,Matthew Bates,Amy S. Piatek,Heather Alexander,Ben J. Marais,Luis E. Cuevas,Timothy D. McHugh,Lynn S. Zijenah,Nathan Kapata,Nathan Kapata,Ibrahim Abubakar,Ibrahim Abubakar,Ruth McNerney,Michael Hoelscher,Ziad A. Memish,Giovanni Battista Migliori,Peter S. Kim,Markus Maeurer,Marco Schito,Alimuddin Zumla +21 more
TL;DR: The development of the Xpert MTB/RIF assay is undoubtedly a landmark event, clinical and programmatic effects and cost-effectiveness remain to be defined, and a rapid, accurate point-of-care diagnostic test that is affordable and can be readily implemented is urgently needed.
Journal ArticleDOI
Rapid determination of anti-tuberculosis drug resistance from whole-genome sequences
Francesc Coll,Ruth McNerney,Mark D. Preston,José Afonso Guerra-Assunção,Andrew Warry,Grant A. Hill-Cawthorne,Grant A. Hill-Cawthorne,Kim Mallard,Mridul Nair,Anabela Miranda,Adriana Alves,João Perdigão,Miguel Viveiros,Isabel Portugal,Zahra Hasan,Rumina Hasan,Judith R. Glynn,Nigel Martin,Arnab Pain,Taane G. Clark +19 more
TL;DR: A library predictive of DR for 15 anti-tuberculosis drugs was compiled and validated for 11 of them using genomic-phenotypic data from 792 strains, and in silico diagnostic accuracy was superior to some commercial diagnostics and alternative databases.
Journal ArticleDOI
A standardised method for interpreting the association between mutations and phenotypic drug resistance in Mycobacterium tuberculosis
Paolo Miotto,Belay Tessema,Elisa Tagliani,Leonid Chindelevitch,Angela M. Starks,Claudia Emerson,Debra Hanna,Peter S. Kim,Richard Liwski,Matteo Zignol,Christopher Gilpin,Stefan Niemann,Claudia M. Denkinger,Joy Fleming,Robin M. Warren,Derrick W. Crook,Derrick W. Crook,James E. Posey,Sebastien Gagneux,Sebastien Gagneux,Sven Hoffner,Sven Hoffner,Camilla Rodrigues,Iñaki Comas,David M. Engelthaler,Megan Murray,David Alland,Leen Rigouts,Christoph Lange,Keertan Dheda,Rumina Hasan,Uma Devi Ranganathan,Ruth McNerney,Matthew Ezewudo,Daniela Maria Cirillo,Marco Schito,Claudio U. Köser,Timothy C. Rodwell,Timothy C. Rodwell +38 more
TL;DR: This study provides a standardised and comprehensive approach for the interpretation of mutations as predictors of M. tuberculosis drug- resistant phenotypes and has implications for the clinical interpretation of molecular diagnostics and next-generation sequencing as well as efficient individualised therapy for patients with drug-resistant tuberculosis.