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Nerea Blanes Ruiz
Researcher at Queen Mary University of London
Publications - 4
Citations - 15
Nerea Blanes Ruiz is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: XIST & X chromosome. The author has co-authored 4 publications.
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Journal ArticleDOI
Emerging Roles of Repetitive and Repeat-Containing RNA in Nuclear and Chromatin Organization and Gene Expression.
TL;DR: In this article, the authors discuss evidence supporting the multifaceted roles of repetitive RNA and RNA binding proteins in nuclear organization, gene regulation, and in the formation of dynamic membrane-less aggregates.
Journal ArticleDOI
RIF1 and KAP1 differentially regulate the choice of inactive versus active X chromosomes.
Elin Enervald,Elin Enervald,Lynn M. Powell,Lora Boteva,Rossana Foti,Nerea Blanes Ruiz,Gözde Kibar,Agnieszka Piszczek,Fatima Cavaleri,Martin Vingron,Andrea Cerase,Sara B.C. Buonomo,Sara B.C. Buonomo +12 more
TL;DR: This article showed that the mutual exclusion of Tsix and RIF1 at the Xist promoters established a self-sustaining loop that transforms an initially stochastic event into a stably inherited asymmetric X-chromosome state.
Journal ArticleDOI
Chd8 regulates X chromosome inactivation in mouse through fine-tuning control of Xist expression.
Andrea Cerase,Alexander N. Young,Alexander N. Young,Nerea Blanes Ruiz,Andreas Buness,Andreas Buness,Gabrielle M Sant,Mirjam Arnold,Mirjam Arnold,Monica Di Giacomo,Michela Ascolani,Manish Kumar,Manish Kumar,Andreas Hierholzer,Andreas Hierholzer,Giuseppe Trigiante,Sarah J. Marzi,Philip Avner +17 more
TL;DR: In this article, the authors demonstrate a new role for Chd8 in Xist regulation in differentiating ES cells, linked to its control and prevention of spurious transcription factor interactions occurring within Xist regulatory regions.
Posted ContentDOI
A RIF1/KAP1-based toggle switch stabilises the identities of the inactive and active X chromosomes during X inactivation
Elin Enervald,Elin Enervald,Lynn M. Powell,Lora Boteva,Rossana Foti,Nerea Blanes Ruiz,Gözde Kibar,Agnieszka Piszczek,Fatima Cavaleri,Martin Vingron,Andrea Cerase,Sara B.C. Buonomo,Sara B.C. Buonomo +12 more
TL;DR: In this article, the authors show that upregulation of the long non-coding RNA Tsix weakens the symmetric RIF1 association with the Xist promoter, and opens a window of opportunity for a more stable association of KAP1.