P
Philip Avner
Researcher at European Bioinformatics Institute
Publications - 151
Citations - 11547
Philip Avner is an academic researcher from European Bioinformatics Institute. The author has contributed to research in topics: XIST & X-inactivation. The author has an hindex of 52, co-authored 148 publications receiving 11061 citations. Previous affiliations of Philip Avner include French Institute of Health and Medical Research & Centre national de la recherche scientifique.
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Journal ArticleDOI
X-chromosome inactivation: counting, choice and initiation
Philip Avner,Edith Heard +1 more
TL;DR: In many sexually dimorphic species, a mechanism is required to ensure equivalent levels of gene expression from the sex chromosomes, and in mammals, such dosage compensation is achieved by X-chromosome inactivation, a process that presents a unique medley of biological puzzles.
Journal ArticleDOI
Characterization of a murine gene expressed from the inactive X chromosome.
Giuseppe Borsani,Rossana Tonlorenzi,M. Christine Simmler,Luisa Dandolo,Danielle Arnaud,Valeria Capra,Markus Grompe,Antonio Pizzuti,Donna M. Muzny,Charles B. Lawrence,Huntington F. Willard,Philip Avner,Andrea Ballabio +12 more
TL;DR: The isolation and characterization of its murine homologue (Xist) is reported which localizes to the mouse X inactivation centre region and is the first murine gene found to be expressed from the inactive X chromosome and may be associated with a protein product.
Journal ArticleDOI
Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.
TL;DR: It is reported that methylation of histone H3 lysine 9 on the inactive X chromosome occurs immediately after Xist RNA coating and before transcriptional inactivation of X-linked genes.
Journal ArticleDOI
X-chromosome inactivation in mammals
TL;DR: The definition of a major role for Xist, a noncoding RNA, in X-inactivation has enabled investigation of the mechanism leading to establishment of the heterochromatinized X-chromosome and also of the interactions between X- inactivation and imprinting as well as between X -inactivation and developmental processes in the early embryo.
Journal ArticleDOI
The nature and identification of quantitative trait loci: a community's view.
Oduola Abiola,Joe M. Angel,Philip Avner,Alexander A. Bachmanov,John K. Belknap,Beth Bennett,Elizabeth P. Blankenhorn,David A. Blizard,Valerie J. Bolivar,Gudrun A. Brockmann,Kari J. Buck,Jean Francois Bureau,William L. Casley,Elissa J. Chesler,James M. Cheverud,Gary A. Churchill,Melloni N. Cook,John C. Crabbe,Wim E. Crusio,Ariel Darvasi,Gerald de Haan,Peter Demant,Rebecca W. Doerge,Rosemary W. Elliott,Charles R. Farber,Lorraine Flaherty,Jonathan Flint,Howard K. Gershenfeld,John P. Gibson,Jing Gu,Weikuan Gu,Heinz Himmelbauer,Robert Hitzemann,Hui-Chen Hsu,Kent W. Hunter,Fuad A. Iraqi,Ritsert C. Jansen,Thomas E. Johnson,Byron C. Jones,Gerd Kempermann,Frank Lammert,Lu Lu,Kenneth F. Manly,Douglas B. Matthews,Juan F. Medrano,Margarete Mehrabian,Guy Mittleman,Beverly A. Mock,Jeffrey S. Mogil,Xavier Montagutelli,Grant Morahan,John D. Mountz,Hiroki Nagase,Richard S. Nowakowski,Bruce F. O'Hara,Alexander V. Osadchuk,Beverly Paigen,Abraham A. Palmer,Jeremy L. Peirce,Daniel Pomp,Michael Rosemann,Glenn D. Rosen,Leonard C. Schalkwyk,Ze'ev Seltzer,Stephen H. Settle,Kazuhiro Shimomura,Siming Shou,James M. Sikela,Linda D. Siracusa,Jimmy L. Spearow,Cory Teuscher,David W. Threadgill,Linda A. Toth,A. A. Toye,Csaba Vadasz,Gary Van Zant,Edward K. Wakeland,Robert W. Williams,Huang-Ge Zhang,Fei Zou +79 more
TL;DR: This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits.