Ngoc B. Pham

TL;DR: An unusual binding mode, with no interactions between the inhibitor molecule and the active site metal ion is previously unobserved for this enzyme class and presents a new opportunity for future drug design campaigns to target a mode of inhibition that differs substantially from classical inhibitors.

TL;DR: A natural product library (NPL) is generated in which 85% of the isolated compounds had no Lipinski violations and demonstrates the feasibility of obtaining natural products known for rich chemical diversity with the required physicochemical properties for drug discovery.

TL;DR: A proof-of-concept experiment to show direct affinity screening using electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI-FTICR-MS) is a rapid and informative approach for natural product extract screening is described.

TL;DR: The diversity of marine natural products that have shown in- vivo efficacy or in-vitro potential against drug-resistant infections of fungal, viral, and parasitic origin are discussed, and their mechanism of action is described.

TL;DR: 96 low-molecular-weight natural products are identified as binding partners of 32 of the putative malarial targets and 79 fragments have direct growth inhibition on Plasmodium falciparum at concentrations that are promising for the development of fragment hits against these protein targets.