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Nicholas A. Duggett
Researcher at Animal and Plant Health Agency
Publications - 18
Citations - 1700
Nicholas A. Duggett is an academic researcher from Animal and Plant Health Agency. The author has contributed to research in topics: Plasmid & Escherichia coli. The author has an hindex of 8, co-authored 16 publications receiving 668 citations. Previous affiliations of Nicholas A. Duggett include University of Warwick.
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Journal ArticleDOI
ResFinder 4.0 for predictions of phenotypes from genotypes.
Valeria Bortolaia,Rolf Sommer Kaas,Etienne Ruppé,Marilyn C. Roberts,Stefan Schwarz,Vincent Cattoir,Alain Philippon,Rosa Lundbye Allesøe,Rosa Lundbye Allesøe,Ana-Rita Rebelo,Alfred Ferrer Florensa,Linda Fagelhauer,Trinad Chakraborty,Bernd Neumann,Guido Werner,Jennifer K. Bender,Kerstin Stingl,Minh Ngoc Nguyen,Jasmine Coppens,Basil Britto Xavier,Surbhi Malhotra-Kumar,Henrik Westh,Henrik Westh,Mette Pinholt,Muna F. Anjum,Nicholas A. Duggett,Isabelle Kempf,Suvi Nykäsenoja,Satu Olkkola,Kinga Wieczorek,Ana Amaro,Lurdes Clemente,Joël Mossong,Serge Losch,Catherine Ragimbeau,Ole Lund,Frank Møller Aarestrup +36 more
TL;DR: WGS-based AST using ResFinder 4.0 provides in silico antibiograms as reliable as those obtained by phenotypic AST at least for the bacterial species/antimicrobial agents of major public health relevance considered.
Journal ArticleDOI
mcr-1 and mcr-2 variant genes identified in Moraxella species isolated from pigs in Great Britain from 2014 to 2015.
Manal AbuOun,Manal AbuOun,Emma Stubberfield,Nicholas A. Duggett,Miranda Kirchner,Luisa Dormer,Javier Nunez-Garcia,Luke P. Randall,Fabrizio Lemma,Derrick W. Crook,Derrick W. Crook,Christopher Teale,Richard P. Smith,Muna F. Anjum,Muna F. Anjum +14 more
TL;DR: The results add further evidence for the mobilization of the mcr-pap2 unit from Moraxella via composite transposons leading to its global dissemination as well as indicating they may comprise a reservoir for mcr.
Journal ArticleDOI
Colistin resistance in Salmonella and Escherichia coli isolates from a pig farm in Great Britain
Muna F. Anjum,Nicholas A. Duggett,Manal AbuOun,Luke P. Randall,Javier Nunez-Garcia,Richard J. Ellis,Jon Rogers,R.A. Horton,Camilla Brena,Susanna Williamson,Francesca Martelli,Robert Davies,Christopher Teale +12 more
TL;DR: The in vitro transfer of multiple plasmids carrying colistin and other resistances from the Salmonella isolate underlines the potential for wider dissemination and recombination of resistance through different horizontally transferable elements.
Journal ArticleDOI
Molecular epidemiology of isolates with multiple mcr plasmids from a pig farm in Great Britain: the effects of colistin withdrawal in the short and long term.
Nicholas A. Duggett,Luke P. Randall,R.A. Horton,Fabrizio Lemma,Miranda Kirchner,Javier Nunez-Garcia,Camilla Brena,Susanna Williamson,Christopher Teale,Muna F. Anjum +9 more
TL;DR: For the first known time on the presence in Great Britain of mcr-3 from MDR Enterobacteriaceae, which might concurrently harbour multiple copies of mCR-1 on different plasmids, which can successfully mitigate long-term on-farm persistence.
Journal ArticleDOI
Occurrence and characterization of mcr-1-harbouring Escherichia coli isolated from pigs in Great Britain from 2013 to 2015.
Nicholas A. Duggett,Ellie Sayers,Ellie Sayers,Manal AbuOun,Richard J. Ellis,Javier Nunez-Garcia,Luke P. Randall,R.A. Horton,Jon Rogers,Francesca Martelli,Richard P. Smith,Camilla Brena,Susanna Williamson,Miranda Kirchner,Robert Davies,Derrick W. Crook,S.J. Evans,Chris Teale,Muna F. Anjum +18 more
TL;DR: In this paper, the occurrence of mcr-1 -harbouring Escherichia coli in archived pig material originating in Great Britain (GB) from 2013 to 2015 and characterize mcr1 plasmids were determined.