N
Nicholas Svitek
Researcher at International Livestock Research Institute
Publications - 34
Citations - 771
Nicholas Svitek is an academic researcher from International Livestock Research Institute. The author has contributed to research in topics: Theileria parva & Immune system. The author has an hindex of 11, co-authored 28 publications receiving 650 citations. Previous affiliations of Nicholas Svitek include Mayo Clinic & Leibniz Association.
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Receptor (SLAM [CD150]) recognition and the V protein sustain swift lymphocyte-based invasion of mucosal tissue and lymphatic organs by a morbillivirus
TL;DR: Findings prove formally that SLAM recognition is necessary for morbillivirus virulence and reveal how two viral proteins affect pathogenesis: V sustains the swift lymphocyte-based invasion of mucosal tissue and lymphatic organs, whereas C sustains subsequent infection phases.
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Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction.
TL;DR: It is observed that the severity of clinical signs correlated with gross- and histopathological changes in the lungs and was subtype-independent, suggesting that more virulent strains may interfere more efficiently with the host response at early disease stages.
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The biology of Theileria parva and control of East Coast fever - Current status and future trends.
Vishvanath Nene,Vishvanath Nene,Henry K. Kiara,Anna Lacasta,Roger Pelle,Nicholas Svitek,Lucilla Steinaa +6 more
TL;DR: The Muguga cocktail ITM vaccine, which provides broad-spectrum immunity to ECF, is now a registered product in three countries in eastern Africa and effort is directed at improving and scaling up the production process to make this vaccine more widely available on a commercial basis in the region.
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Local Innate Immune Responses and Influenza Virus Transmission and Virulence in Ferrets
Taronna R. Maines,Jessica A. Belser,Kortney M. Gustin,Neal Van Hoeven,Hui Zeng,Nicholas Svitek,Veronika von Messling,Jacqueline M. Katz,Terrence M. Tumpey +8 more
TL;DR: A strong temporal correlation between inflammatory mediators and the kinetics and frequency of transmission, clinical signs associated with transmission, peak virus shedding, and virulence is found and points to a link between localized innate immunity and influenza virus transmission and disease progression.
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Early Cytokine mRNA Expression Profiles Predict Morbillivirus Disease Outcome in Ferrets
TL;DR: The newly developed cytokine assays strengthen and expand the ferret model not only for Morbillivirus pathogenesis studies but also for several other human respiratory viruses including influenza and SARS.