Henry K. Kiara

TL;DR: The Muguga cocktail ITM vaccine, which provides broad-spectrum immunity to ECF, is now a registered product in three countries in eastern Africa and effort is directed at improving and scaling up the production process to make this vaccine more widely available on a commercial basis in the region.

TL;DR: The nPCR assay represents a highly sensitive tool for detection and monitoring of asymptomatic carrier state infections of T. parva in the blood of cattle and was compared to a previously described p104-based PCR and also the reverse line blot technique.

TL;DR: It is demonstrated that this degree of heterologous protection provides a unifying explanation for apparently disparate epidemiological patterns: variable disease-induced mortality rates, age-mortality profiles, weak correlations between the incidence of infection and disease (known as endemic stability), and poor efficacy of interventions that reduce exposure to multiple parasite species.

TL;DR: There is a need to consider co-infections in epidemiological studies as opposed to single-pathogen focus, and benefits of an integrated approach to helminths and East Coast fever disease control are suggested.

TL;DR: The results support ancient zebu × AT admixture in the EASZ population, subsequently shaped by selection and/or genetic drift, followed by a more recent exotic European cattle introgression.