Nicola Doherty

TL;DR: UK Biobank is not representative of the sampling population; there is evidence of a “healthy volunteer” selection bias; valid assessment of exposure-disease relationships may be widely generalizable and does not require participants to be Representative of the population at large.

TL;DR: An in-depth overview of the imaging enhancement of the UK Biobank, including the data collected, how it is managed and processed, and future directions is provided.

TL;DR: In this paper, the authors evaluated the impact of radiologists flagging with potentially serious findings in a multi-modal imaging study of 100,000 participants, compared with a systematic radiologist review of all images.

TL;DR: The impact of radiographer ‘flagging’ with radiologist confirmation of potentially serious IFs in a multi-modal imaging study of 100,000 participants compared with systematic radiologist review is evaluated to suggest radiographer flagging is a justifiable approach in the UK Biobank imaging study.

TL;DR: This study is the largest so far to investigate the factors associated with PSIFs and serious final diagnoses, and may have missed some associations due to sparsity of these outcomes within this cohort and small numbers within some exposure categories.