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Lorna Gibson

Researcher at University of London

Publications -  77
Citations -  10600

Lorna Gibson is an academic researcher from University of London. The author has contributed to research in topics: Breast cancer & Population. The author has an hindex of 34, co-authored 73 publications receiving 9062 citations. Previous affiliations of Lorna Gibson include Edinburgh Royal Infirmary & International Agency for Research on Cancer.

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Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

Bjarni J. Vilhjálmsson, +394 more
TL;DR: LDpred is introduced, a method that infers the posterior mean effect size of each marker by using a prior on effect sizes and LD information from an external reference panel, and outperforms the approach of pruning followed by thresholding, particularly at large sample sizes.
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Large-scale genotyping identifies 41 new loci associated with breast cancer risk

Kyriaki Michailidou, +220 more
- 01 Apr 2013 - 
TL;DR: A meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, and identified 29,807 SNPs for further genotyping suggests that more than 1,000 additional loci are involved in breast cancer susceptibility.
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MicroRNA related polymorphisms and breast cancer risk

Sofia Khan, +161 more
- 12 Nov 2014 - 
TL;DR: Five miRNA binding site SNPs associated significantly with breast cancer risk are located in the 3′ UTR of CASP8, HDDC3, DROSHA, MUSTN1, and MYCL1, respectively, which belongs to miRNA machinery genes and has a central role in initial miRNA processing.
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A common coding variant in CASP8 is associated with breast cancer risk

Angela Cox, +84 more
- 11 Feb 2007 - 
TL;DR: It is demonstrated that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies, as well as the need for further studies to confirm putative genetic associations with breast cancer.