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Thomas J. Littlejohns
Researcher at University of Oxford
Publications - 54
Citations - 3798
Thomas J. Littlejohns is an academic researcher from University of Oxford. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 16, co-authored 35 publications receiving 2113 citations. Previous affiliations of Thomas J. Littlejohns include University of Exeter & University of York.
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Journal ArticleDOI
Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population.
Anna Fry,Thomas J. Littlejohns,Catherine Sudlow,Nicola Doherty,Ligia Adamska,Tim Sprosen,Rory Collins,Naomi E. Allen +7 more
TL;DR: UK Biobank is not representative of the sampling population; there is evidence of a “healthy volunteer” selection bias; valid assessment of exposure-disease relationships may be widely generalizable and does not require participants to be Representative of the population at large.
Journal ArticleDOI
Vitamin D and the risk of dementia and Alzheimer disease
Thomas J. Littlejohns,William Henley,Iain A. Lang,Cédric Annweiler,Olivier Beauchet,Paulo H M Chaves,Linda P. Fried,Bryan Kestenbaum,Lewis H. Kuller,Kenneth M. Langa,Oscar L. Lopez,Katarina Kos,Maya Soni,David J. Llewellyn +13 more
TL;DR: It is confirmed that vitamin D deficiency is associated with a substantially increased risk of all-cause dementia and Alzheimer disease, and adds to the ongoing debate about the role of vitamin D in nonskeletal conditions.
Journal ArticleDOI
Association of Lifestyle and Genetic Risk With Incidence of Dementia
Ilianna Lourida,Eilis Hannon,Thomas J. Littlejohns,Kenneth M. Langa,Elina Hyppönen,Elzbieta Kuzma,Elzbieta Kuzma,David J. Llewellyn,David J. Llewellyn +8 more
TL;DR: Among older adults without cognitive impairment or dementia, both an unfavorable lifestyle and high genetic risk were significantly associated with higher dementia risk, while a favorable lifestyle was associated with a lower dementia risk among participants with high Genetic risk.
Journal ArticleDOI
The UK Biobank imaging enhancement of 100,000 participants: rationale, data collection, management and future directions
Thomas J. Littlejohns,Jo Holliday,Lorna Gibson,Lorna Gibson,Steve Garratt,Niels Oesingmann,Fidel Alfaro-Almagro,Jimmy D. Bell,Chris Boultwood,Rory Collins,Megan Conroy,Nicola Crabtree,Nicola Doherty,Alejandro F. Frangi,Alejandro F. Frangi,Nicholas C. Harvey,Paul Leeson,Karla L. Miller,Stefan Neubauer,Steffen E. Petersen,Jonathan Sellors,Simon Sheard,Stephen M. Smith,Cathie Sudlow,Paul M. Matthews,Naomi E. Allen +25 more
TL;DR: An in-depth overview of the imaging enhancement of the UK Biobank, including the data collected, how it is managed and processed, and future directions is provided.
Journal ArticleDOI
'Vitamin D and cognition in older adults': Updated international recommendations
Cédric Annweiler,Cédric Annweiler,Erdinç Dursun,Francois Feron,Duygu Gezen-Ak,Allan V. Kalueff,Thomas J. Littlejohns,David J. Llewellyn,Pascal Millet,Tammy Scott,Katherine L. Tucker,Selma Yilmazer,Olivier Beauchet +12 more
TL;DR: Hypovitaminosis D, a condition that is highly prevalent in older adults aged 65 years and above, is associated with brain changes and dementia and clear guidance is needed for researchers and clinicians.