N
Nicola Zanesi
Researcher at Ohio State University
Publications - 83
Citations - 8521
Nicola Zanesi is an academic researcher from Ohio State University. The author has contributed to research in topics: FHIT & Cancer. The author has an hindex of 35, co-authored 83 publications receiving 7925 citations. Previous affiliations of Nicola Zanesi include Thomas Jefferson University & University of Padua.
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Journal ArticleDOI
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
Andrea Vecchione,Gustavo Baldassarre,Hideshi Ishii,Milena S. Nicoloso,Barbara Belletti,Fabio Petrocca,Nicola Zanesi,Louise Y.Y. Fong,Sabrina Battista,Daniela Guarnieri,Raffaele Baffa,Hansjuerg Alder,John L. Farber,Peter J. Donovan,Carlo M. Croce +14 more
TL;DR: In Lzts1(-/-) mouse embryo fibroblasts (MEFs), Cdc25C degradation was increased during M phase, resulting in decreased Cdk1 activity, which was associated with an increased incidence of both spontaneous and carcinogen-induced cancers in mice.
Journal ArticleDOI
Molecular basis of CLL.
TL;DR: Molecular details of how activation of TCL1, a critical oncogene in aggressive CLL, results in the initiation of this malignancy were clarified and importance of these pathways was supported by investigations of several mouse models of CLL.
Journal ArticleDOI
Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)
Alexey Palamarchuk,Pearlly S. Yan,Nicola Zanesi,Linan Wang,Benjamin Rodrigues,Mark W. Murphy,Veronica Balatti,Arianna Bottoni,Natalya Nazaryan,Hansjuerg Alder,Laura Z. Rassenti,Thomas J. Kipps,Michael A. Freitas,Carlo M. Croce,Yuri Pekarsky +14 more
TL;DR: Results suggest that inhibition of de novo DNA methylation may be a common oncogenic mechanism in leukemogenesis.
Journal Article
Genetic mapping of lung cancer modifier loci specifically affecting tumor initiation and progression
Giacomo Manenti,Manuela Gariboldi,Antonio Fiorino,Nicola Zanesi,Marco A. Pierotti,Tommaso A. Dragani +5 more
TL;DR: Mouse inbred strains with inherited predisposition and resistance to lung cancer provide a tool for the dissection of the complex genetics of this disease, and the present results provide evidence for the existence of cancer modifier loci acting on specific stages of lung tumorigenesis.
Journal ArticleDOI
Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice.
Crystina L. Kriss,Javier Pinilla-Ibarz,Adam W. Mailloux,John Powers,Chih-Hang Anthony Tang,Chang Won Kang,Nicola Zanesi,Pearlie K. Epling-Burnette,Eduardo M. Sotomayor,Carlo M. Croce,Juan R. Del Valle,Chih-Chi Andrew Hu +11 more
TL;DR: It is shown for the first time that the previously unexplored endoplasmic reticulum (ER) stress response is aberrantly activated in Eμ-TCL1 mouse and human CLL, and the ER stress-response pathway is a novel molecular target for the treatment of CLL.