P
Peter J. Donovan
Researcher at Royal Brisbane and Women's Hospital
Publications - 167
Citations - 14129
Peter J. Donovan is an academic researcher from Royal Brisbane and Women's Hospital. The author has contributed to research in topics: Stem cell & Embryonic stem cell. The author has an hindex of 52, co-authored 154 publications receiving 13508 citations. Previous affiliations of Peter J. Donovan include Johns Hopkins University & National Institutes of Health.
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Journal ArticleDOI
Derivation of pluripotent stem cells from cultured human primordial germ cells
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Paul D. Blumenthal,George R. Huggins,John D. Gearhart +8 more
TL;DR: In this article, a set of primordial germ cells (PGCs, 5-9 weeks postfertilization) were cultured on mouse STO fibroblast feeder layers in the presence of human recombinant leukemia inhibitory factor (HILI) and forskolin.
Derivation of pluripotent stem cells from cultured human primordial germ cells (alkaline phosphataseyembryoid bodyyembryonic stem cellyembryonic germ cell)
Michael J. Shamblott,Joyce Axelman,Shunping Wang,Elizabeth M. Bugg,John W. Littlefield,Peter J. Donovan,Aul D. Blumenthal,R. Huggins,John D. Gearhart +8 more
TL;DR: Based on their origin and demonstrated properties, these human PGC-derived cultures meet the criteria for pluripotent stem cells and most closely resemble EG cells.
Journal ArticleDOI
Long-term proliferation of mouse primordial germ cells in culture.
TL;DR: This work reports a further factor that stimulates PGC proliferation in vitro, basic fibroblast growth factor (bFGF), which, in the presence of steel factor and leukaemia inhibitory factor, stimulates long-term proliferation of PGCs, leading to the derivation of large colonies of cells.
Journal ArticleDOI
Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles.
Neal G. Copeland,Debra J. Gilbert,Brian C. Cho,Peter J. Donovan,Nancy A. Jenkins,David Cosman,Dirk M. Anderson,Stewart D. Lyman,Douglas E. Williams +8 more
TL;DR: The cloning of sequences encoding MGF, a c-kit ligand, is described and it is shown that Mgf maps near Sl in the distal region of mouse chromosome 10 and is deleted in a number of Sl alleles, strongly support the notion that Sl encodes the mast cell growth factor.
Journal ArticleDOI
Requirement for mast cell growth factor for primordial germ cell survival in culture
Susanna Dolci,Douglas E. Williams,Mary K. Ernst,James L. Resnick,Camilynn I. Brannan,Leslie F. Lock,Stewart D. Lyman,Boswell Hs,Peter J. Donovan +8 more
TL;DR: It is reported that MGF is essential for PGC survival in culture, but does not stimulate PGC proliferation, thus explaining the sterility in mice carrying the steel-dickie (Sld) mutation.