Nicolai B. Larsen

TL;DR: BLM has been shown to play a critical role in homologous recombination at multiple steps, including end-resection, displacement loop formation, branch migration and double Holliday junction dissolution, and recent evidence has revealed a role for BLM/Sgs1 in the stabilisation and repair of replication forks damaged during a perturbed S-phase.

TL;DR: D detection of diabetic retinopathy by automated detection of single fundus lesions can be achieved with a performance comparable to that of experienced ophthalmologists, and the results warrant further investigation of automated fundus image analysis as a tool for diabetic Retinopathy screening.

TL;DR: It is shown that when DPC proteolysis is blocked, the replicative DNA helicase CMG (CDC45, MCM2-7, GINS), which travels on the leading strand template, bypasses an intact leading strand DPC.

TL;DR: The degree of agreement between subjectively and objectively assessed retinal thickening was very good, implying that changes in diabetic macular edema can be accurately and prospectively measured with OCT.

TL;DR: It is shown that DPCs can be degraded by SPRTN or the proteasome, which act as independent DPC proteases, and are coupled to DNA replication by distinct mechanisms that promote replication across immovable protein barriers.