Nicolas Dutzan

TL;DR: This study provides a global-scale framework for the ecological events in subgingival communities that underline the development of periodontitis and elucidate the relationship between inflammation and the subgesival microbiome.

TL;DR: A characterization of the progression ofperiodontitis as a stage that presents a significantly host immune and inflammatory response to the microbial challenge that determine of susceptibility to develop the destructive/progressive periodontitis under the influence of multiple behavioral, environmental and genetic factors.

TL;DR: The authors showed that defective neutrophil recruitment to the periodontal space in LAD-I patients or in LFA-1–deficient mice was associated with excessive production of the inflammatory cytokine IL-17, mostly from T cells, and provided an alternative mechanism by showing that the cytokine interleukin-17 (IL-17) plays a major role in the oral pathology of L AD-I.

TL;DR: An expansion of resident memory T helper 17 (TH17) cells in human periodontitis is demonstrated and this study highlights distinct functions of TH17 cells in oral immunity and inflammation and paves the way to a new targeted therapeutic approach for the treatment ofperiodontitis.

TL;DR: The total amount of cytokine IL-17 in GCF samples and in the culture supernatants of gingival cells are significantly increased in periodontal disease.