T
Triantafyllos Chavakis
Researcher at Dresden University of Technology
Publications - 269
Citations - 17924
Triantafyllos Chavakis is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Inflammation & Innate immune system. The author has an hindex of 65, co-authored 242 publications receiving 13247 citations. Previous affiliations of Triantafyllos Chavakis include National Institutes of Health & University of Edinburgh.
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Journal ArticleDOI
Defining trained immunity and its role in health and disease
Mihai G. Netea,Mihai G. Netea,Jorge Domínguez-Andrés,Luis B. Barreiro,Luis B. Barreiro,Triantafyllos Chavakis,Triantafyllos Chavakis,Maziar Divangahi,Maziar Divangahi,Elaine Fuchs,Leo A. B. Joosten,Jos W. M. van der Meer,Musa M. Mhlanga,Musa M. Mhlanga,Willem J. M. Mulder,Willem J. M. Mulder,Niels P. Riksen,Andreas Schlitzer,Joachim L. Schultze,Christine Stabell Benn,Joseph C. Sun,Joseph C. Sun,Ramnik J. Xavier,Ramnik J. Xavier,Eicke Latz,Eicke Latz,Eicke Latz +26 more
TL;DR: A group of leaders in the field define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
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Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity
Ioannis Mitroulis,Klara Ruppova,Baomei Wang,Lan Sun Chen,Michal Grzybek,Tatyana Grinenko,Anne Eugster,Maria Troullinaki,Alessandra Palladini,Ioannis Kourtzelis,Antonios Chatzigeorgiou,Andreas Schlitzer,Marc Beyer,Marc Beyer,Leo A. B. Joosten,Berend Isermann,Mathias Lesche,Andreas Petzold,Kai Simons,Ian Henry,Andreas Dahl,Joachim L. Schultze,Joachim L. Schultze,Ben Wielockx,Nicola Zamboni,Peter Mirtschink,Ünal Coskun,George Hajishengallis,Mihai G. Netea,Mihai G. Netea,Triantafyllos Chavakis +30 more
TL;DR: The trained-immunity-related increase in myelopoiesis resulted in a beneficial response to secondary LPS challenge and protection from chemotherapy-induced myelosuppression in mice, suggesting modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity.
Journal ArticleDOI
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo
Abigail Woodfin,Mathieu-Benoit Voisin,Martina Beyrau,Bartomeu Colom,Dorothée Caille,Frantzeska-Maria Diapouli,Gerard B. Nash,Triantafyllos Chavakis,Steven M. Albelda,G. Ed Rainger,Paolo Meda,Beat A. Imhof,Sussan Nourshargh +12 more
TL;DR: The results identify JAM-C as a key regulator of polarized neutrophil TEM in vivo and suggest that reverse TEM of neutrophils can contribute to the dissemination of systemic inflammation.
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Metabolic Induction of Trained Immunity through the Mevalonate Pathway
Siroon Bekkering,Rob J.W. Arts,Boris Novakovic,Ioannis Kourtzelis,Charlotte D C C van der Heijden,Yang Li,Calin D. Popa,Rob ter Horst,Julia van Tuijl,Romana T. Netea-Maier,Frank L. van de Veerdonk,Triantafyllos Chavakis,Leo A. B. Joosten,Jos W. M. van der Meer,Henk Stunnenberg,Niels P. Riksen,Mihai G. Netea,Mihai G. Netea +17 more
TL;DR: It is reported that metabolic signals can induce trained immunity and the role of mevalonate in trained immunity contributes to the understanding of the pathophysiology of HIDS and identifies novel therapeutic targets for clinical conditions with excessive activation of trained immunity.
Journal ArticleDOI
Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters
Juergen Graessler,Youwen Qin,Huanzi Zhong,Jia Zhang,Julio Licinio,Ma-Li Wong,Aimin Xu,Triantafyllos Chavakis,A Bornstein,Monika Ehrhart-Bornstein,V Lamounier-Zepter,T Lohmann,T Wolf,Stefan R. Bornstein +13 more
TL;DR: This is the first clinical demonstration of a profound and specific intra-individual modification of gut microbial composition by full metagenomic sequencing in morbidly obese patients with T2D, and a clear correlation exists of microbiome composition and gene function with an improvement in metabolic and inflammatory parameters.