Nicolas Morin

TL;DR: The results suggest that the C3aR in macrophages, and potentially adipocytes, plays an important role in adipose tissue homeostasis and insulin resistance.

TL;DR: It is demonstrated that under a HFD, ctsk deficiency confers a partial resistance to the development of dyslipidemia and ctsK ablation in mice results in reduced body fat content under conditions requiring a rapid accumulation of fat stores.

TL;DR: A weak, UDP-competitive antagonist of the pyrimidinergic receptor P2RY(14) with a naphthoic acid core was identified through high-throughput screening and optimization provided compounds with improved potency but poor pharmacokinetics.

TL;DR: The series of competitive antagonists against the G-protein coupled receptor P2Y(14) were found to be highly shifted in the presence of serum and led to the identification of the zwitterion 2, which is substantially less shifted than the previous lead compound 1.

TL;DR: Compound 18q was identified as a 10 nM P2Y(14) antagonist with good oral bioavailability and provided sufficient exposure in mice to be used as a tool for future in vivo studies.