M
Margherita Maffei
Researcher at National Research Council
Publications - 77
Citations - 24261
Margherita Maffei is an academic researcher from National Research Council. The author has contributed to research in topics: Adipose tissue & Leptin. The author has an hindex of 34, co-authored 71 publications receiving 23423 citations. Previous affiliations of Margherita Maffei include Rockefeller University & University of Pisa.
Papers
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Journal ArticleDOI
Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
Journal ArticleDOI
Weight-Reducing Effects of the Plasma Protein Encoded by the obese Gene
Jeffrey L. Halaas,Gajiwala Ketan,Margherita Maffei,Steven L. Cohen,Brian T. Chait,Daniel Rabinowitz,Roger Lallone,Stephen K. Burley,Jeffrey M. Friedman +8 more
TL;DR: Injection of wild-type mice twice daily with the mouse protein resulted in a sustained 12 percent weight loss, decreased food intake, and a reduction of body fat from 12.2 to 0.7 percent, suggesting that the OB protein serves an endocrine function to regulate body fat stores.
Journal ArticleDOI
Leptin levels in human and rodent : Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
Margherita Maffei,Jeffrey L. Halaas,Eric Ravussin,Richard E. Pratley,Gwo-Hwa Lee,Gwo-Hwa Lee,Yan Zhang,Yan Zhang,Hong Fei,S. Kim,R. Lallone,S. Ranganathan,Philip A. Kern,Philip A. Kern,Jeffrey M. Friedman,Jeffrey M. Friedman +15 more
TL;DR: Weight loss due to food restriction was associated with a decrease in plasma leptin in samples from mice and obese humans, suggesting differences in its secretion rate from fat.
Journal ArticleDOI
Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus.
Margherita Maffei,Hong Fei,Gwo-Hwa Lee,Christian Dani,Pascale Leroy,Yiying Zhang,Richardo Proenca,Raymond Negrel,Gérard Ailhaud,Jeffrey M. Friedman +9 more
TL;DR: In db/db and lesioned mice, quantitative differences in expression level of ob RNA correlated with adipocyte lipid content, suggesting that both the db gene and the hypothalamus are downstream of the ob gene in the pathway that regulates adipose tissue mass.
Patent
Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
Jeffrey M. Friedman,Yiying Zhang,Ricardo Proenca,Margherita Maffei,Jeffrey L. Halaas,Gajiwala Ketan,Stephen K. Burley +6 more
TL;DR: In this paper, a method for modulating body weight of a mammal is provided, based on the elucidation and discovery of nucleotide sequences, and proteins expressed by such nucleotides or degenerate variations thereof.