V
Valérie Vingtdeux
Researcher at university of lille
Publications - 53
Citations - 4616
Valérie Vingtdeux is an academic researcher from university of lille. The author has contributed to research in topics: AMPK & Amyloid precursor protein. The author has an hindex of 26, co-authored 53 publications receiving 4034 citations. Previous affiliations of Valérie Vingtdeux include North Shore-LIJ Health System & French Institute of Health and Medical Research.
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Journal ArticleDOI
AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism
Valérie Vingtdeux,Luca Giliberto,Haitian Zhao,Pallavi Chandakkar,Qingli Wu,James E. Simon,Elsa M. Janle,Jessica Lobo,Mario G. Ferruzzi,Peter Davies,Peter Davies,Philippe Marambaud,Philippe Marambaud +12 more
TL;DR: It is shown that AMPK signaling controls Aβ metabolism and mediates the anti-amyloidogenic effect of resveratrol in non-neuronal and neuronal cells, including in mouse primary neurons, and that resver atrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease.
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Massive CA1/2 Neuronal Loss with Intraneuronal and N-Terminal Truncated Aβ42 Accumulation in a Novel Alzheimer Transgenic Model
Caty Casas,Nicolas Sergeant,Jean-Michel Itier,Véronique Blanchard,Oliver Wirths,Nicolien M. van der Kolk,Valérie Vingtdeux,Evita van de Steeg,Gwenaelle Ret,Thierry Canton,Hervé Drobecq,Allan Clark,Bruno Bonici,André Delacourte,Jesus Benavides,Christoph Schmitz,Gunter Tremp,Thomas A. Bayer,Patrick Benoit,Laurent Pradier +19 more
TL;DR: A transgenic mouse model, APP(SL)PS1KI, was presented in this article that closely mimics the development of AD-related neuropathological features including a significant hippocampal neuronal loss.
Journal ArticleDOI
CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes
Akiyuki Taruno,Valérie Vingtdeux,Makoto Ohmoto,Zhongming Ma,Gennady Dvoryanchikov,Ang Li,Ang Li,Leslie Adrien,Haitian Zhao,Sze Leung,Maria Abernethy,Jeremy Koppel,Peter Davies,Peter Davies,Mortimer M. Civan,Nirupa Chaudhari,Ichiro Matsumoto,Göran Hellekant,Michael G. Tordoff,Philippe Marambaud,J. Kevin Foskett +20 more
TL;DR: It is shown that calcium homeostasis modulator 1 (CALHM1), a voltage-gated ion channel, is indispensable for taste-stimuli-evoked ATP release from sweet-, bitter- and umami-sensing taste bud cells.
Journal ArticleDOI
Resveratrol mitigates lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade.
Hemachander Capiralla,Valérie Vingtdeux,Haitian Zhao,Roman Sankowski,Yousef Al-Abed,Peter Davies,Peter Davies,Philippe Marambaud +7 more
TL;DR: The authors showed that resveratrol, a natural polyphenol associated with anti-inflammatory effects and currently in clinical trials for AD, prevented the activation of macrophages and microglial BV-2 cells treated with TLR4 ligand, lipopolysaccharide (LPS).
Journal ArticleDOI
A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk
Ute Dreses-Werringloer,Jean-Charles Lambert,Valérie Vingtdeux,Haitian Zhao,Horia Vais,Adam P. Siebert,Ankit Jain,Jeremy Koppel,Anne Rovelet-Lecrux,Didier Hannequin,Florence Pasquier,Daniela Galimberti,Elio Scarpini,David M. A. Mann,Corinne Lendon,Dominique Campion,Philippe Amouyel,Peter Davies,Peter Davies,J. Kevin Foskett,Fabien Campagne,Philippe Marambaud,Philippe Marambaud +22 more
TL;DR: It is proposed that CALHM1 encodes an essential component of a previously uncharacterized cerebral Ca(2+) channel that controls Abeta levels and susceptibility to late-onset AD.