M
Marie-Christine Galas
Researcher at university of lille
Publications - 15
Citations - 1055
Marie-Christine Galas is an academic researcher from university of lille. The author has contributed to research in topics: Tau protein & Alzheimer's disease. The author has an hindex of 11, co-authored 15 publications receiving 803 citations. Previous affiliations of Marie-Christine Galas include Lille University of Science and Technology.
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Journal ArticleDOI
Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau Protein
Simon Dujardin,Séverine Bégard,Raphaëlle Caillierez,Cédrick Lachaud,Lucie Delattre,Sébastien Carrier,Anne Loyens,Marie-Christine Galas,Luc Bousset,Ronald Melki,Gwennaelle Auregan,Philippe Hantraye,Emmanuel Brouillet,Luc Buée,Morvane Colin +14 more
TL;DR: It is found that Tau is predominately secreted in ectosomes, which are plasma membrane-originating vesicles, and when it accumulates, the exosomal pathway is activated.
Journal ArticleDOI
Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies.
Valérie Vingtdeux,Malika Hamdane,Anne Loyens,Patrick Gelé,Hervé Drobeck,Séverine Bégard,Marie-Christine Galas,André Delacourte,Jean-Claude Beauvillain,Luc Buée,Nicolas Sergeant +10 more
TL;DR: The data show that multivesicular bodies are essential organelles for APP metabolism and that all APP metabolites can be secreted in the extracellular space.
Journal ArticleDOI
Atypical, non-standard functions of the microtubule associated Tau protein
Ioannis Sotiropoulos,Marie-Christine Galas,Joana Silva,Efthimios M. C. Skoulakis,Susanne Wegmann,Mahmoud Bukar Maina,David Blum,Carmen Laura Sayas,Eva-Maria Mandelkow,Eckhard Mandelkow,Maria Grazia Spillantini,Nuno Sousa,Jesús Avila,Miguel Medina,Amrit Mudher,Luc Buée +15 more
TL;DR: Atypical, non-standard roles of Tau on neuronal function and dysfunction in AD and other neurological pathologies providing novel insights about neuroplastic and neuropathological implications of Tau in both the central and the peripheral nervous system are focused on.
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Beneficial effects of exercise in a transgenic mouse model of Alzheimer's disease-like Tau pathology.
Karim Belarbi,Sylvie Burnouf,Francisco-Jose Fernandez-Gomez,Cyril Laurent,Sophie Lestavel,Martin Figeac,Audrey Sultan,Laetitia Troquier,Antoine Leboucher,Raphaëlle Caillierez,Marie-Eve Grosjean,Dominique Demeyer,Hélène Obriot,I. Brion,B. Barbot,Marie-Christine Galas,Bart Staels,Sandrine Humez,Nicolas Sergeant,Susanna Schraen-Maschke,Anne Muhr-Tailleux,Malika Hamdane,Luc Buée,David Blum +23 more
TL;DR: The data support the view that long-term voluntary physical exercise is an effective strategy capable of mitigating Tau pathology and its pathophysiological consequences, and prevent memory alterations in THY-Tau22 mice.
Journal ArticleDOI
Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin.
Zeyni Mansuroglu,Houda Benhelli-Mokrani,Vasco Marcato,Audrey Sultan,Marie Violet,Alban Chauderlier,Lucie Delattre,Anne Loyens,Smail Talahari,Séverine Bégard,Fabrice Nesslany,Morvane Colin,Sylvie Souès,Bruno Lefebvre,Luc Buée,Marie-Christine Galas,Eliette Bonnefoy +16 more
TL;DR: It is demonstrated that Tau, a protein involved in a number of neurodegenerative diseases including Alzheimer’s disease (AD), binds to and localizes within or next to neuronal PCH in primary neuronal cultures from wild-type mice and is disrupted in neurons from Tau-deficient mice.