E
Emanuela Colombo
Researcher at European Institute of Oncology
Publications - 46
Citations - 5619
Emanuela Colombo is an academic researcher from European Institute of Oncology. The author has contributed to research in topics: Nucleophosmin & Biology. The author has an hindex of 28, co-authored 40 publications receiving 5035 citations. Previous affiliations of Emanuela Colombo include University of Milan.
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Journal ArticleDOI
Cytoplasmic Nucleophosmin in Acute Myelogenous Leukemia with a Normal Karyotype
Brunangelo Falini,Christina Mecucci,Enrico Tiacci,Myriam Alcalay,Roberto Rosati,Laura Pasqualucci,Roberta La Starza,Daniela Diverio,Emanuela Colombo,Antonella Santucci,Barbara Bigerna,Roberta Pacini,Alessandra Pucciarini,Arcangelo Liso,Marco Vignetti,Paola Fazi,Natalia Meani,Valentina Pettirossi,Giuseppe Saglio,Franco Mandelli,Francesco Lo-Coco,Pier Giuseppe Pelicci,Massimo F. Martelli +22 more
TL;DR: Cytoplasmic NPM is a characteristic feature of a large subgroup of patients with AML who have a normal karyotype, NPM gene mutations, and responsiveness to induction chemotherapy.
Journal ArticleDOI
Astrocytes: Key Regulators of Neuroinflammation.
Emanuela Colombo,Cinthia Farina +1 more
TL;DR: In vivo studies on astrocyte signaling in neuroinflammatory models focusing on evidences obtained from the analysis of transgenic mice are re-visited, clarifying precise signaling steps, highlighting the crosstalk among pathways and identifies shared effector mechanisms in neuroinflammation.
Journal ArticleDOI
Nucleophosmin regulates the stability and transcriptional activity of p53.
Emanuela Colombo,Jean-Christophe Marine,Davide Danovi,Brunangelo Falini,Pier Giuseppe Pelicci +4 more
TL;DR: It is shown that NPM interacts directly with the tumour suppressor p53, regulates the increase in stability and transcriptional activation of p53 after different types of stress, and induces p53-dependent premature senescence on overexpression in diploid fibroblasts.
Journal ArticleDOI
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance.
Myriam Alcalay,Enrico Tiacci,Roberta Bergomas,Barbara Bigerna,Elisa Venturini,Simone Minardi,Natalia Meani,Daniela Diverio,Loris Bernard,Laura Tizzoni,Sara Volorio,Lucilla Luzi,Emanuela Colombo,Francesco Lo Coco,Cristina Mecucci,B. Falini,Pier Giuseppe Pelicci +16 more
TL;DR: The molecular signature of NPMc+ AML includes up-regulation of several genes putatively involved in the maintenance of a stem-cell phenotype, suggesting that NPM c- AML may derive from a multipotent hematopoietic progenitor.
Journal ArticleDOI
Oligomerization of RAR and AML1 Transcription Factors as a Novel Mechanism of Oncogenic Activation
Saverio Minucci,Marco Maccarana,Mario Cioce,Pasquale De Luca,Vania Gelmetti,Simona Segalla,Luciano Di Croce,Sabrina Giavara,Cristian Matteucci,Alberto Gobbi,Andrea Bianchini,Emanuela Colombo,Ilaria Schiavoni,Ilaria Schiavoni,Gianfranco Badaracco,Xiao Hu,Mitchell A. Lazar,Nicoletta Landsberger,Clara Nervi,Pier Giuseppe Pelicci +19 more
TL;DR: The results show that oligomerization of a transcription factor, imposing an altered interaction with transcriptional coregulators, represents a novel mechanism of oncogenic activation.