Mario Cioce

TL;DR: It is found that oncogenic Ras upregulates PML expression, and overexpression of PML induces senescence in a p53-dependent manner, and integrity of the PML bodies is required for p53 acetylation and senescences upon oncogene expression.

TL;DR: This review surveys what is known about the structure and function of the subnuclear domains called Cajal bodies, and considers the interesting links that have emerged between CBs and alterations in nuclear structure apparent in a range of human pathologies.

TL;DR: The results show that oligomerization of a transcription factor, imposing an altered interaction with transcriptional coregulators, represents a novel mechanism of oncogenic activation.

TL;DR: It is suggested that DICER modulation, mir33a upregulation and c-MYC targeting have an important role in the anticancer metabolic effects of metformin.

TL;DR: It is shown that pemetrexed-treated mesothelioma cells undergo accelerated senescence, characterized by the secretion of proinflammatory and mitogenic cytokines, reminiscent of an SASP (senescence-associated secretory phenotype), and that small hairpin RNA-mediated ablation of STAT3 deeply attenuates the induction of EMT genes and the increase of ALDHbright cells induced by SASP-cytokines.