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Nicolò Scalacci
Researcher at King's College London
Publications - 9
Citations - 486
Nicolò Scalacci is an academic researcher from King's College London. The author has contributed to research in topics: Catalysis & Cascade reaction. The author has an hindex of 6, co-authored 9 publications receiving 338 citations. Previous affiliations of Nicolò Scalacci include Northumbria University.
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Journal ArticleDOI
Synthesis and Reactivity of Propargylamines in Organic Chemistry
TL;DR: The different synthetic approaches to synthesize propargylamines, such as A3 couplings and C-H functionalization of alkynes, have been described and organized on the basis of the catalysts employed in the syntheses.
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Unveiling the Biocatalytic Aromatizing Activity of Monoamine Oxidases MAO-N and 6-HDNO: Development of Chemoenzymatic Cascades for the Synthesis of Pyrroles
Nicolò Scalacci,Nicolò Scalacci,Gary W. Black,Giulio Mattedi,Nicola Brown,Nicholas J. Turner,Daniele Castagnolo +6 more
TL;DR: A chemoenzymatic cascade process for the sustainable production of pyrroles has been developed, exploiting the previously unexplored aromatizing activity of monoamine oxidase enzymes (MAO-N and 6-HDNO) to synthesize Pyrroles.
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Design and Synthesis of 1-((1,5-Bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl)methyl)-4-methylpiperazine (BM212) and N-Adamantan-2-yl-N '-((E)-3,7-dimethylocta-2,6-dienyl)ethane-1,2-diamine (SQ109) Pyrrole Hybrid Derivatives: Discovery of Potent Antitubercular Agents Effective against Multidrug-Resistant Mycobacteria
Sanjib Bhakta,Nicolò Scalacci,Nicolò Scalacci,Arundhati Maitra,Alistair K. Brown,Alistair K. Brown,Saiprasad Dasugari,Dimitrios Evangelopoulos,Timothy D. McHugh,Parisa Nakhostin Mortazavi,Alexander Twist,Elena Petricci,Fabrizio Manetti,Daniele Castagnolo,Daniele Castagnolo +14 more
TL;DR: Six compounds showed potent inhibition (comparable to that of verapamil) toward the whole-cell drug efflux pump activity of mycobacteria, thus turning out to be promising multidrug-resistance-reversing agents.
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Rethinking the old antiviral drug moroxydine: Discovery of novel analogues as anti-hepatitis C virus (HCV) agents.
Andrea Magri,Roisin Reilly,Nicolò Scalacci,Marco Radi,Michael Hunter,Manon Ripoll,Arvind H. Patel,Daniele Castagnolo +7 more
TL;DR: The discovery of a novel class of HCV inhibitors designed as isosteric analogues of the antiviral drug moroxydine and synthesized in only three synthetic steps from cheap building blocks and in high yields, thus turning to be promising drug candidates in the development of cheaper HCV treatments.
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Synthesis and SAR evaluation of novel thioridazine derivatives active against drug-resistant tuberculosis
Nicolò Scalacci,Alistair K. Brown,Fernando Rogério Pavan,Camila Maríngolo Ribeiro,Fabrizio Manetti,Sanjib Bhakta,Arundhati Maitra,Darren Smith,Elena Petricci,Daniele Castagnolo +9 more
TL;DR: A small library of thioridazine derivatives has been designed through the replacement of the piperidine and phenothiazine moieties, with the aim to improve the anti-tubercular activity and to reduce the cytotoxic effects.