M
Meggy Suarez-Carmona
Researcher at German Cancer Research Center
Publications - 25
Citations - 1572
Meggy Suarez-Carmona is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Cancer & Immunotherapy. The author has an hindex of 16, co-authored 25 publications receiving 1111 citations. Previous affiliations of Meggy Suarez-Carmona include University Hospital Heidelberg & University of Liège.
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Journal ArticleDOI
EMT and inflammation: inseparable actors of cancer progression
TL;DR: The interconnections between EMT programs and cellular and molecular actors of inflammation are described, and data linking the EMT/inflammation axis to metastasis is recapitulate.
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Tumoral Immune Cell Exploitation in Colorectal Cancer Metastases Can Be Targeted Effectively by Anti-CCR5 Therapy in Cancer Patients.
Niels Halama,Niels Halama,Inka Zoernig,Anna Berthel,Christoph Kahlert,Fee Klupp,Meggy Suarez-Carmona,Thomas Suetterlin,Thomas Suetterlin,Karsten Brand,Juergen Krauss,Felix Lasitschka,Tina Lerchl,Tina Lerchl,Claudia Luckner-Minden,Alexis Ulrich,Moritz Koch,Juergen Weitz,Martin Schneider,Markus W. Buechler,Laurence Zitvogel,Thomas R. W. Herrmann,Axel Benner,Christina Kunz,Stephan Luecke,Christoph Springfeld,Niels Grabe,Niels Grabe,Christine S. Falk,Dirk Jaeger,Dirk Jaeger +30 more
TL;DR: Analyzing the invasive margin of human CRC liver metastases, a mechanism of immune cell exploitation by tumor cells was identified and Mitigation of tumor-promoting inflammation within the tumor tissue and objective tumor responses in CRC were observed.
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Topography of cancer-associated immune cells in human solid tumors
Jakob Nikolas Kather,Meggy Suarez-Carmona,Meggy Suarez-Carmona,Pornpimol Charoentong,Pornpimol Charoentong,Cleo-Aron Weis,Daniela Hirsch,Peter Bankhead,Marcel Horning,Dyke Ferber,Dyke Ferber,Ivan Kel,Esther Herpel,Sarah Schott,Inka Zörnig,Inka Zörnig,Jochen Utikal,Jochen Utikal,Alexander Marx,Timo Gaiser,H Brenner,Jenny Chang-Claude,Jenny Chang-Claude,Michael Hoffmeister,Dirk Jäger,Dirk Jäger,Niels Halama,Niels Halama +27 more
TL;DR: It is shown that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients.
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Defensins: « simple » antimicrobial peptides or broad-spectrum molecules ?
TL;DR: Recent research works regarding the diversified functions of defensins are described, by mainly focusing on human models, to help clarify their roles in the adaptive immune system and angiogenesis and determinant players in male fertility.
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In silico modeling of immunotherapy and stroma-targeting therapies in human colorectal cancer
Jakob Nikolas Kather,Jakob Nikolas Kather,Jan Poleszczuk,Meggy Suarez-Carmona,Meggy Suarez-Carmona,Johannes Krisam,Pornpimol Charoentong,Pornpimol Charoentong,Nektarios A. Valous,Nektarios A. Valous,Cleo-Aron Weis,Luca Tavernar,Florian Leiss,Esther Herpel,Fee Klupp,Alexis Ulrich,Martin Schneider,Alexander Marx,Dirk Jäger,Dirk Jäger,Niels Halama,Niels Halama +21 more
TL;DR: Simulation of immunotherapy in preestablished tumors showed that a complex landscape with optimal stroma permeabilization and immune cell activation is able to markedly increase therapy response in silico These results can help guide the rational design of complex therapeutic interventions, which target the colorectal cancer microenvironment.