N
Nikolai Malinin
Researcher at Weizmann Institute of Science
Publications - 12
Citations - 3536
Nikolai Malinin is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: MAP kinase kinase kinase & FADD. The author has an hindex of 9, co-authored 12 publications receiving 3472 citations.
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Journal ArticleDOI
TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
David Wallach,Eugene Varfolomeev,Nikolai Malinin,Yuri V. Goltsev,and A. V. Kovalenko,Mark Boldin +5 more
TL;DR: The molecules that initiate these signaling events, including the death domain- and TNF receptor associated factor (TRAF) domain-containing adapter proteins and the signaling enzymes associated with them, are largely unique to the TNF/nerve growth factor receptor family.
Journal ArticleDOI
MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1.
TL;DR: The findings indicate that NIK participates in an NF-KB-inducing signalling cascade common to receptors of the TNF/NGF family and to the interleukin-1 type-I receptor.
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Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways
Helmut Holtmann,Reinhard Winzen,Pamela M. Holland,Solveig Eickemeier,Elke Hoffmann,David Wallach,Nikolai Malinin,Jonathan A. Cooper,Klaus Resch,Michael Kracht +9 more
TL;DR: Evidence is provided that maximal IL-8 gene expression requires the coordinate action of at least three different signal transduction pathways which cooperate to induce mRNA synthesis and suppress mRNA degradation.
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CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-κB and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-κB-inducing Kinase *
Hisaya Akiba,Hiroyasu Nakano,Shigeyuki Nishinaka,Masahisa Shindo,Tetsuji Kobata,Machiko Atsuta,Chikao Morimoto,Carl F. Ware,Nikolai Malinin,David Wallach,Hideo Yagita,Ko Okumura +11 more
TL;DR: Results indicate that TRAF2 and TRAF5 are involved in NF-κB and SAPK/JNK activation by CD27, and NIK is a common downstream kinase of TRAF 2 and TRAf5 for NF-πάδ2 and SAPk/J NK activation.
Journal ArticleDOI
Epstein–Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NF-κB through a pathway that includes the NF-κB-inducing kinase and the IκB kinases IKKα and IKKβ
Bakary S. Sylla,Siu Chun Hung,David Davidson,Eudoxia Hatzivassiliou,Nikolai Malinin,David Wallach,Thomas D. Gilmore,Elliott Kieff,George Mosialos +8 more
TL;DR: It is shown that NF-κB activation by LMP1 or by each of its effector sites is mediated by a pathway that includes NIK, IKKα, and IKKβ.