R
Reinhard Winzen
Researcher at Hannover Medical School
Publications - 22
Citations - 2491
Reinhard Winzen is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Messenger RNA & MAP kinase kinase kinase. The author has an hindex of 17, co-authored 22 publications receiving 2433 citations. Previous affiliations of Reinhard Winzen include Martin Luther University of Halle-Wittenberg.
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Journal ArticleDOI
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
Reinhard Winzen,Michael Kracht,Birgit Ritter,Arno Wilhelm,Chyi-Ying A. Chen,Ann-Bin Shyu,Monika Müller,Matthias Gaestel,Klaus Resch,Helmut Holtmann +9 more
TL;DR: Findings indicate that the p38 MAP kinase pathway contributes to cytokine/stress‐induced gene expression by stabilizing mRNAs through an MK2‐dependent, ARE‐targeted mechanism.
Journal ArticleDOI
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels.
Armin Neininger,Dimitris L. Kontoyiannis,Alexey Kotlyarov,Reinhard Winzen,Rolf Eckert,Hans-Dieter Volk,Helmut Holtmann,George Kollias,Matthias Gaestel +8 more
TL;DR: The data provide in vivo evidence that the AU-rich 3′-UTRs of TNF and IL-6 are downstream to MK2 signaling and make MK2 an essential component of mechanisms that regulate biosynthesis of IL- 6 at the levels of mRNA stability, and of T NF mainly through TNF-ARE-dependent translational control.
Journal ArticleDOI
Induction of Interleukin-8 Synthesis Integrates Effects on Transcription and mRNA Degradation from at Least Three Different Cytokine- or Stress-Activated Signal Transduction Pathways
Helmut Holtmann,Reinhard Winzen,Pamela M. Holland,Solveig Eickemeier,Elke Hoffmann,David Wallach,Nikolai Malinin,Jonathan A. Cooper,Klaus Resch,Michael Kracht +9 more
TL;DR: Evidence is provided that maximal IL-8 gene expression requires the coordinate action of at least three different signal transduction pathways which cooperate to induce mRNA synthesis and suppress mRNA degradation.
Journal ArticleDOI
Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets.
Reinhard Winzen,Basant Kumar Thakur,Oliver Dittrich-Breiholz,Meera Shah,Natalie Redich,Sonam Dhamija,Michael Kracht,Helmut Holtmann +7 more
TL;DR: Results indicate that KSRP functions as a limiting factor in inflammatory gene expression, and evidence that TTP, a target of MK2, can also destabilize the IL-8 ARE reporter mRNA is presented.
Journal ArticleDOI
Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR.
Reinhard Winzen,Gayatri Gowrishankar,Frank Bollig,Natalie Redich,Klaus Resch,Helmut Holtmann +5 more
TL;DR: These results show that distinct ARE domains differ in function with regard to destabilization, stabilization by p38/MK2 activation, and stabilization by HuR.