N
Nikolaus D. Obholzer
Researcher at Harvard University
Publications - 29
Citations - 2322
Nikolaus D. Obholzer is an academic researcher from Harvard University. The author has contributed to research in topics: Zebrafish & Gene. The author has an hindex of 16, co-authored 25 publications receiving 1798 citations. Previous affiliations of Nikolaus D. Obholzer include Brigham and Women's Hospital & Loyola University Chicago.
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Journal ArticleDOI
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
Veit Rothhammer,Ivan D. Mascanfroni,Lukas Bunse,Maisa C. Takenaka,Jessica E. Kenison,Lior Mayo,Chun-Cheih Chao,Bonny Patel,Raymond Yan,Manon Blain,Jorge I. Alvarez,Hania Kebir,Niroshana Anandasabapathy,Guillermo Izquierdo,Steffen Jung,Nikolaus D. Obholzer,Nikolaus D. Obholzer,Nathalie Pochet,Nathalie Pochet,Clary B. Clish,Marco Prinz,Alexandre Prat,Jack P. Antel,Francisco J. Quintana +23 more
TL;DR: Findings suggest that IFN-Is produced in the CNS function in combination with metabolites derived from dietary tryptophan by the gut flora to activate AHR signaling in astrocytes and suppress CNS inflammation.
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Vesicular Glutamate Transporter 3 Is Required for Synaptic Transmission in Zebrafish Hair Cells
Nikolaus D. Obholzer,Sean N. Wolfson,Josef G. Trapani,Weike Mo,Alex Nechiporuk,Elisabeth Busch-Nentwich,Elisabeth Busch-Nentwich,Christoph Seiler,Christoph Seiler,Samuel Sidi,Samuel Sidi,Christian Söllner,Christian Söllner,Robert N. Duncan,Andrea Boehland,Teresa Nicolson +15 more
TL;DR: It is reported that asteroid, a gene identified in an ethylnitrosourea mutagenesis screen of zebrafish larvae for auditory/vestibular mutants, encodes vesicular glutamate transporter 3 (Vglut3), which contains insufficient levels of glutamate for generation of action potentials in first-order neurons.
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Association of Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 with pathological diagnosis of Alzheimer disease.
Lei Yu,Lori B. Chibnik,Gyan Srivastava,Gyan Srivastava,Nathalie Pochet,Nathalie Pochet,Jingyun Yang,Jishu Xu,Jishu Xu,James A. Kozubek,James A. Kozubek,Nikolaus D. Obholzer,Nikolaus D. Obholzer,Sue Leurgans,Julie A. Schneider,Alexander Meissner,Alexander Meissner,Philip L. De Jager,David A. Bennett +18 more
TL;DR: Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 was associated with pathological AD, and the results provide further evidence that disruption ofDNA methylation is involved in the pathological process of AD.
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Specified Neural Progenitors Sort to Form Sharp Domains after Noisy Shh Signaling
Fengzhu Xiong,Andrea R. Tentner,Peng Huang,Arnaud Gelas,Kishore R. Mosaliganti,Lydie Souhait,Nicolas Rannou,Ian A. Swinburne,Nikolaus D. Obholzer,Paul D. Cowgill,Alexander F. Schier,Sean G. Megason +11 more
TL;DR: This work finds that specified progenitors of different fates are spatially mixed following heterogeneous Sonic Hedgehog signaling responses, and reveals that cell sorting acts to correct imprecision of spatial patterning by noisy inductive signals.
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Ribeye is required for presynaptic CaV1.3a channel localization and afferent innervation of sensory hair cells
TL;DR: Modulated Ribeye expression in zebrafish hair cells reveals two distinct functions of Ribeye in ribbon synapse formation – clustering CaV1.3a channels at the presynapse and stabilizing contacts with afferent neurons – and suggest that Ribeye plays an organizing role in synaptogenesis.