N
Nils E. Magnusson
Researcher at Aarhus University
Publications - 54
Citations - 2605
Nils E. Magnusson is an academic researcher from Aarhus University. The author has contributed to research in topics: Sunitinib & Angiogenesis. The author has an hindex of 25, co-authored 54 publications receiving 2288 citations. Previous affiliations of Nils E. Magnusson include Aarhus University Hospital & Max Planck Society.
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Journal ArticleDOI
Gene expression profiling: monitoring transcription and translation products using DNA microarrays and proteomics.
Julio E. Celis,Mogens Kruhøffer,Irina Gromova,Casper M Frederiksen,Morten Østergaard,Thomas Thykjaer,Pavel Gromov,Jinsheng Yu,Hildur Palsdottir,Nils E. Magnusson,Torben F. Ørntoft +10 more
TL;DR: The current status of DNA microarrays and proteomics is reviewed and some studies in which they have been applied in concert to the analysis of biopsy specimens are highlighted.
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Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells
Burak Kutlu,Alessandra K Cardozo,Martine I. Darville,Mogens Kruhøffer,Nils E. Magnusson,Torben F. Ørntoft,Decio L. Eizirik +6 more
TL;DR: Changes in the expression of genes related to metabolism, signal transduction, and transcription factors at all time points studied indicate beta-cell attempts to adapt to the effects of continuous cytokine exposure and the role of NO for these modifications in gene expression is revealed.
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Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.
Fernanda Ortis,Pierre Pirot,Najib Naamane,A Y Kreins,Joanne Rasschaert,Francis D. Moore,E Théâtre,Catherine Verhaeghe,Nils E. Magnusson,Alain Chariot,Torben F. Ørntoft,Decio L. Eizirik +11 more
TL;DR: NF-κB activation in beta cells has a pro-apoptotic role following exposure not only to IL-1β but also to TNF-α, which is explained at least in part by higher intensity NF-κBs activation, leading to increased transcription of key target genes.
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Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs
Pierre Pirot,Najib Naamane,Frédérick Libert,Nils E. Magnusson,Torben F. Ørntoft,Alessandra K Cardozo,Decio L. Eizirik +6 more
TL;DR: This study provides the first global analysis of beta cell molecular responses to a severe ER stress, and identifies the early degradation of mRNA transcripts of the insulin genes as an important component of this response.
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Growing tissues in real and simulated microgravity: new methods for tissue engineering.
Daniela Grimm,Markus Wehland,Jessica Pietsch,Ganna Aleshcheva,Petra Wise,Jack J. W. A. van Loon,Claudia Ulbrich,Nils E. Magnusson,Manfred Infanger,Johann Bauer +9 more
TL;DR: 3D tissue engineering in simulated and real microgravity represents a new strategy for tissue engineering of a variety of tissues, such as regenerated cartilage, artificial vessel constructs, and other organ tissues as well as multicellular cancer spheroids.