Nina Neuhaus

TL;DR: This review aims to provide an update on clinical practices and experimental methods, as well as to describe patient management inclusion strategies used to preserve and restore the fertility of prepubertal boys at high risk of fertility loss.

TL;DR: Interestingly, testicular histology was highly heterogeneous irrespective of the treatment strategy, a phenomenon that requires further investigation.

TL;DR: It is suggested that spermatogonia are adapted to the individual reproductive lifespan and that the life-long sperm output from a sperMatogonium is balanced against the duration of a generation, and the risk of jeopardizing genome integrity is balancedAgainst a maximized sperm output.

TL;DR: There is a need for more individualized and better‐controlled cross‐sex hormone therapy and post‐treatment regimens, and evidence‐based guidelines for attending clinicians need to be established in order to deliver the most appropriate care.

TL;DR: It is demonstrated that mutations in M1AP are a relatively frequent cause of autosomal recessive severe spermatogenic failure and male infertility with strong clinical validity.