N
Nisse Kalkkinen
Researcher at University of Helsinki
Publications - 223
Citations - 16734
Nisse Kalkkinen is an academic researcher from University of Helsinki. The author has contributed to research in topics: Peptide sequence & Amino acid. The author has an hindex of 65, co-authored 223 publications receiving 16113 citations. Previous affiliations of Nisse Kalkkinen include University of Eastern Finland & Orion Corporation.
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A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.
Vladimir Joukov,Katri Pajusola,Arja Kaipainen,Dmitri Chilov,Isto Lahtinen,Eola Kukk,Olli Saksela,Nisse Kalkkinen,Kari Alitalo +8 more
TL;DR: VEGF‐C is a novel regulator of endothelia, and its effects may extend beyond the lymphatic system, where Flt4 is expressed.
Journal Article
A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases (vol 15, pg 290, 1996)
Vladimir Joukov,Katri Pajusola,Arja Kaipainen,Dmitri Chilov,Isto Lahtinen,Eola Kukk,Olli Saksela,Nisse Kalkkinen,Kari Alitalo +8 more
Journal ArticleDOI
Proteolytic processing regulates receptor specificity and activity of VEGF-C
Vladimir Joukov,Tarja Sorsa,Vijay Kumar,Michael Jeltsch,Lena Claesson-Welsh,Yihai Cao,Olli Saksela,Nisse Kalkkinen,Kari Alitalo +8 more
TL;DR: The role of post‐translational processing in VEGF‐C secretion and function is analysed, and novel structure–function relationships in the PDGF/VEGF family are revealed.
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Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
Päivi Lindholm,Merja H. Voutilainen,Juha Lauren,Juha Lauren,Johan Peränen,Veli-Matti Leppänen,Jaan-Olle Andressoo,Maria Lindahl,Sanna Janhunen,Sanna Janhunen,Nisse Kalkkinen,Tõnis Timmusk,Tõnis Timmusk,Raimo K. Tuominen,Mart Saarma +14 more
TL;DR: In vivo and in vivo, CDNF prevented the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat experimental model of Parkinson’s disease and suggest that CDNF might be beneficial for the treatment of Parkinson's disease.
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Isolation, characterization, molecular gene cloning, and sequencing of a novel phytase from Bacillus subtilis.
TL;DR: The phytase gene (phyC) was cloned from the B. subtilis VTT E-68013 genomic library and showed no homology to the sequences of other phytases nor to those of any known phosphatases, and therefore PhyC appears not to be a member of thephytase subfamily of histidine acid phosphatase but a novel enzyme having phyt enzyme activity.