J
Juha Lauren
Researcher at Yale University
Publications - 28
Citations - 3866
Juha Lauren is an academic researcher from Yale University. The author has contributed to research in topics: Neurotrophic factors & Myelin. The author has an hindex of 14, co-authored 28 publications receiving 3604 citations. Previous affiliations of Juha Lauren include Massachusetts Institute of Technology & University of Helsinki.
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Journal ArticleDOI
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers
TL;DR: The cellular prion protein (PrPC) is identified as an amyloid-β-oligomer receptor by expression cloning, and PrPC-specific pharmaceuticals may have therapeutic potential for Alzheimer’s disease.
Journal ArticleDOI
Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo
Päivi Lindholm,Merja H. Voutilainen,Juha Lauren,Juha Lauren,Johan Peränen,Veli-Matti Leppänen,Jaan-Olle Andressoo,Maria Lindahl,Sanna Janhunen,Sanna Janhunen,Nisse Kalkkinen,Tõnis Timmusk,Tõnis Timmusk,Raimo K. Tuominen,Mart Saarma +14 more
TL;DR: In vivo and in vivo, CDNF prevented the 6-hydroxydopamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat experimental model of Parkinson’s disease and suggest that CDNF might be beneficial for the treatment of Parkinson's disease.
Journal ArticleDOI
Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein
David A. Gimbel,Haakon B. Nygaard,Erin E. Coffey,Erik C. Gunther,Juha Lauren,Zachary A. Gimbel,Stephen M. Strittmatter +6 more
TL;DR: Examination of familial AD transgenes encoding APPswe and PSen1ΔE9 into Prnp−/− mice shows the necessity of PrPC for AD-related phenotypes, with cognitive deficits selectively requiring PrPC.
Journal ArticleDOI
An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers.
Michael W. Linhoff,Juha Lauren,Juha Lauren,Robert Cassidy,Frederick A. Dobie,Hideto Takahashi,Haakon B. Nygaard,Matti S. Airaksinen,Stephen M. Strittmatter,Ann Marie Craig,Ann Marie Craig +10 more
TL;DR: An unbiased expression screen for synaptogenic proteins in the coculture assay using custom-made cDNA libraries suggests a prevalence of LRR domain proteins in trans-synaptic signaling and provides a cellular basis for the reported linkage of LRRTM1 to handedness and schizophrenia.
Journal ArticleDOI
LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia
Clyde Francks,Shinji Maegawa,Juha Lauren,Brett S. Abrahams,Antonio Velayos-Baeza,Sarah E. Medland,Sarah E. Medland,Stefano Colella,Matthias Groszer,E. Z. McAuley,Tara M. Caffrey,Tõnis Timmusk,Priit Pruunsild,Indrek Koppel,Penelope A. Lind,N. Matsumoto-Itaba,Jérôme Nicod,Lan Xiong,Ridha Joober,Wolfgang Enard,B. Krinsky,Eiji Nanba,Anthony J. Richardson,Brien P. Riley,Nicholas G. Martin,Stephen M. Strittmatter,H.-J. Möller,Dan Rujescu,D. St Clair,Pierandrea Muglia,J. L. Roos,Simon E. Fisher,Richard Wade-Martins,Guy A. Rouleau,John F. Stein,Maria Karayiorgou,Daniel H. Geschwind,Jiannis Ragoussis,K. S. Kendler,Matti S. Airaksinen,Mitsuo Oshimura,Lynn E. DeLisi,Anthony P. Monaco +42 more
TL;DR: It is shown that LRRTM1 is expressed during the development of specific forebrain structures, and thus could influence neuronal differentiation and connectivity, and the first putative genetic effect on variability in human brain asymmetry is found.