Nobuhiro Yamada

TL;DR: The effect of lifestyle modification on improving the glycemic control of patients with established type 2 diabetes mellitus was small but significant three years after initiation of the intervention.

TL;DR: The results indicate that the presence of apolipoprotein E is a major determinant of the metabolic fate of VLDL particles and support the hypothesis that polyvalent binding of particles containing several molecules of apotolipopprotein E promotes receptor-dependent endocytosis of hepatogenous lipoproteins and limits their conversion to lipoproteinins of higher density.

TL;DR: The risk engine accurately predicts macro- and microvascular complications in type 2 diabetes and would provide helpful information in risk classification and health economic simulations.

TL;DR: It is concluded that the injected apoE is incorporated into VLDLs and that V LDL particles carrying more apo E are removed from the blood more rapidly, resulting in reduced formation of low density lipoprotein and lowered cholesterol levels.

TL;DR: Results indicate that activation of SREBP-2 in beta-cells caused severe diabetes by loss of beta-cell mass with accumulation of cholesterol, providing a new lipotoxic model and a potential link of disturbed cholesterol metabolism to impairment ofBeta-cell function.