N
Nobuhiro Yamada
Researcher at University of Tsukuba
Publications - 402
Citations - 27466
Nobuhiro Yamada is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Diabetes mellitus & Cholesterol. The author has an hindex of 82, co-authored 402 publications receiving 25572 citations. Previous affiliations of Nobuhiro Yamada include University of Tokyo & Kyoto University.
Papers
More filters
Journal ArticleDOI
Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy.
Hirohito Sone,Hirohito Sone,Yasushi Kawakami,Arno K. Kumagai,Yukichi Okuda,Yasuo Sekine,Sachiko Honmura,Segawa Toshiaki,Hideo Suzuki,Kamejiro Yamashita,Nobuhiro Yamada +10 more
TL;DR: It is demonstrated that a neutralizing antibody against VEGF was highly effective in the treatment of intraocular neovascularization and suggested possible modes of therapy in human intraocularNeovascular diseases, including diabetic proliferative retinopathy.
Journal ArticleDOI
Hormone-sensitive lipase is involved in hepatic cholesteryl ester hydrolysis
Motohiro Sekiya,Jun-ichi Osuga,Naoya Yahagi,Hiroaki Okazaki,Yoshiaki Tamura,Masaki Igarashi,Satoru Takase,Kenji Harada,Sachiko Okazaki,Yoko Iizuka,Ken Ohashi,Hiroaki Yagyu,Mitsuyo Okazaki,Takanari Gotoda,Ryozo Nagai,Takashi Kadowaki,Hitoshi Shimano,Nobuhiro Yamada,Shun Ishibashi,Shun Ishibashi +19 more
TL;DR: Sekiya et al. as mentioned in this paper found that mice lacking both leptin and HSL (Lep ob/ob /HSL 2/2 ) showed mas- sive accumulation of acylglycerol and cholesteryl ester (CE) in the liver compared with Lep ob /ob / HSL 1/1 mice, while triacyl glycerol (TG) accumulation was modest.
Journal ArticleDOI
Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: Results from 1-year outcomes in the Japanese REACH Registry
Shinichiro Uchiyama,Shinya Goto,Masayasu Matsumoto,Ryozo Nagai,Hideki Origasa,Tsutomu Yamazaki,Hiroshi Shigematsu,Kazuyuki Shimada,Nobuhiro Yamada,Deepak L. Bhatt,P. Gabriel Steg,Yasuo Ikeda +11 more
TL;DR: Overall, event rates including non-fatal stroke, non-Fatal myocardial infarction and cardiovascular death were higher for patients with CVD and PAD than for Patients with CVC and CAD.
Journal ArticleDOI
Sterol Regulatory Element–Binding Protein-1 Determines Plasma Remnant Lipoproteins and Accelerates Atherosclerosis in Low-Density Lipoprotein Receptor–Deficient Mice
Tadayoshi Karasawa,Akimitsu Takahashi,Ryo Saito,Motohiro Sekiya,Masaki Igarashi,Hitoshi Iwasaki,Shoko Miyahara,Saori Koyasu,Yoshimi Nakagawa,Kiyo-aki Ishii,Takashi Matsuzaka,Kazuto Kobayashi,Naoya Yahagi,Kazuhiro Takekoshi,Hirohito Sone,Shigeru Yatoh,Hiroaki Suzuki,Nobuhiro Yamada,Hitoshi Shimano +18 more
TL;DR: Hepatic SREBP-1c determines plasma triglycerides and remnant cholesterol and contributes to atherosclerosis in hyperlipidemic states and regulates the size of nascent VLDL particles.
Journal ArticleDOI
HMG-CoA reductase inhibitor decreases small dense low-density lipoprotein and remnant-like particle cholesterol in patients with type-2 diabetes
Hirohito Sone,Akimitsu Takahashi,Hitoshi Shimano,Shun Ishibashi,Gen Yoshino,Nobuhiro Morisaki,Yasushi Saito,Shoji Kawazu,Tamio Teramoto,Toshiro Fujita,Teruo Shiba,Yasuhiko Iwamoto,Nobuaki Kuzuya,Yasuo Akanuma,Nobuhiro Yamada +14 more
TL;DR: Pitavastatin, which is known to improve triglyceride levels and cholesterol levels, also improves RLP-C level and LDL subfraction profiles, and this in turn may reduce the cardiovascular risk in patients with type 2 diabetes and dyslipidemia.