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Nobuhiro Yamada
Researcher at University of Tsukuba
Publications - 402
Citations - 27466
Nobuhiro Yamada is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Diabetes mellitus & Cholesterol. The author has an hindex of 82, co-authored 402 publications receiving 25572 citations. Previous affiliations of Nobuhiro Yamada include University of Tokyo & Kyoto University.
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Journal ArticleDOI
Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement
Hiraku Ono,Hitoshi Shimano,Hideki Katagiri,Naoya Yahagi,Hideyuki Sakoda,Yukiko Onishi,Motonobu Anai,Takehide Ogihara,Midori Fujishiro,Amelia Y.I. Viana,Yasushi Fukushima,Miho Abe,Nobuhiro Shojima,Masatoshi Kikuchi,Nobuhiro Yamada,Yoshitomo Oka,Tomoichiro Asano +16 more
TL;DR: The sterol regulatory element binding protein (SREBP)-1c contribution to these phenotypic features, myr-Akt adenovirus was injected into SREBP-1 knockout mice, and it was found that SRE BP-1 is not absolutely necessary for the hepatic Akt-mediated hypoglycemic effect.
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Serum level of triglycerides is a potent risk factor comparable to LDL cholesterol for coronary heart disease in Japanese patients with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study (JDCS).
Hirohito Sone,Sachiko Tanaka,Shiro Tanaka,Satoshi Iimuro,Koji Oida,Yoshimitsu Yamasaki,Shinichi Oikawa,Shun Ishibashi,Shigehiro Katayama,Yasuo Ohashi,Yasuo Akanuma,Nobuhiro Yamada +11 more
TL;DR: In Japanese patients with type 2 diabetes, the serum triglyceride level was a leading predictor of CHD, comparable to LDL cholesterol, and ethnic group-specific strategies for prevention of diabetic macroangiopathy may be indicated.
Journal ArticleDOI
SREBP-1 Interacts with Hepatocyte Nuclear Factor-4α and Interferes with PGC-1 Recruitment to Suppress Hepatic Gluconeogenic Genes
Takashi Yamamoto,Hitoshi Shimano,Yoshimi Nakagawa,Tomohiro Ide,Naoya Yahagi,Takashi Matsuzaka,Masanori Nakakuki,Akimitsu Takahashi,Hiroaki Suzuki,Hirohito Sone,Hideo Toyoshima,Ryuichiro Sato,Nobuhiro Yamada +12 more
TL;DR: The data indicate that SREBP-1 has a novel role as negative regulator of gluconeogenic genes through a cross-talk with HNF-4α interference with PGC-1 recruitment.
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Is the diagnosis of metabolic syndrome useful for predicting cardiovascular disease in asian diabetic patients? Analysis from the Japan Diabetes Complications Study.
Hirohito Sone,Sachiko Mizuno,Hitomi Fujii,Yukio Yoshimura,Yoshimitsu Yamasaki,Shun Ishibashi,Shigehiro Katayama,Yasushi Saito,Hideki Ito,Yasuo Ohashi,Yasuo Akanuma,Nobuhiro Yamada +11 more
TL;DR: It is found that MetS is relatively common in diabetic patients with no history of CVD, and commonly used definitions of MetS, at least in their present forms, have limited clinical usefulness for Asian diabetic patients and may need some ethnic group-specific modifications for global use.
Journal ArticleDOI
Prevalence of Metabolic Syndrome in the General Japanese Population in 2000
Hidenori Arai,Akira Yamamoto,Yuji Matsuzawa,Yasushi Saito,Nobuhiro Yamada,Shinichi Oikawa,Hiroshi Mabuchi,Tamio Teramoto,Jun Sasaki,Noriaki Nakaya,Hiroshige Itakura,Yuichi Ishikawa,Yasuyoshi Ouchi,Hiroshi Horibe,Nobuo Shirahashi,Toru Kita +15 more
TL;DR: In the Japanese general population in 2000, visceral obesity was associated with metabolic abnormalities, such as higher LDL-ch cholesterol, triglyceride, glucose, and blood pressure and lower HDL-cholesterol and the association of visceral obesity with metabolic abnormality was found.