N
Nobuhiro Yamada
Researcher at University of Tsukuba
Publications - 402
Citations - 27466
Nobuhiro Yamada is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Diabetes mellitus & Cholesterol. The author has an hindex of 82, co-authored 402 publications receiving 25572 citations. Previous affiliations of Nobuhiro Yamada include University of Tokyo & Kyoto University.
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Absence of Cd36 mutation in the original spontaneously hypertensive rats with insulin resistance.
Takanari Gotoda,Yoko Iizuka,Norihiro Kato,Jun-ichi Osuga,Marie-Thérèse Bihoreau,Toru Murakami,Yukio Yamori,Hitoshi Shimano,Shun Ishibashi,Nobuhiro Yamada +9 more
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Insulin Up-regulates Tumor Necrosis Factor-α Production in Macrophages through an Extracellular-regulated Kinase-dependent Pathway
Kaoruko Iida,Hitoshi Shimano,Yasushi Kawakami,Hirohito Sone,Hideo Toyoshima,Seiji Suzuki,Tomoichiro Asano,Yukichi Okuda,Nobuhiro Yamada +8 more
TL;DR: Observations indicate that insulin stimulates TNF-α production in macrophages by regulating the expression of T NF-α mRNA and that the extracellular signal-regulated kinase signaling pathway may have a critical role in stimulating the production of TNI-α in response to insulin in Macrophages.
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Expression of platelet-derived growth factor beta receptor on human monocyte-derived macrophages and effects of platelet-derived growth factor BB dimer on the cellular function.
Toshiya Inaba,Hitoshi Shimano,Takanari Gotoda,K Harada,Masako Shimada,Jun-ichi Ohsuga,Y Watanabe,Masako Kawamura,Yoshio Yazaki,Nobuhiro Yamada +9 more
TL;DR: The expression of PDGF-beta receptor on human monocyte-derived macrophages suggests that PDGF influences the process of atherosclerosis by regulating the function of macrophage as well as smooth muscle cells in the vascular wall.
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Insulin Inhibits Apoptosis of Macrophage Cell Line, THP-1 Cells, via Phosphatidylinositol-3-Kinase–Dependent Pathway
Kaoruko Iida,Hiroaki Suzuki,Hirohito Sone,Hitoshi Shimano,Hideo Toyoshima,Shigeru Yatoh,Tomoichiro Asano,Yukichi Okuda,Nobuhiro Yamada +8 more
TL;DR: The data indicate that the survival effect of insulin on the apoptosis of macrophages is associated with the upregulation of Bcl-XL expression, and it may be mediated through the phosphatidylinositol-3-kinase signaling pathway.
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Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase: ―発生工学的手法による解析―
Jun-ichi Osuga,Masako Shimada,Shun Ishibashi,Hiroaki Yagyu,Kenji Harada,Ken Ohashi,Nobuhiro Yamada,Yoshio Yazaki +7 more
TL;DR: It is suggested that the altered lipoprotein profile, in particular the reduced level of remnant lipoproteins, is mainly responsible for the protection by LPL against atherosclerosis.