N
Norihiro Shibui
Researcher at Kyoto University
Publications - 6
Citations - 129
Norihiro Shibui is an academic researcher from Kyoto University. The author has contributed to research in topics: Dorsal raphe nucleus & Serotonergic. The author has an hindex of 5, co-authored 6 publications receiving 81 citations.
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Journal ArticleDOI
Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats.
Naoya Nishitani,Kazuki Nagayasu,Kazuki Nagayasu,Nozomi Asaoka,Mayumi Yamashiro,Chihiro Andoh,Yuma Nagai,Haruko Kinoshita,Hiroyuki Kawai,Norihiro Shibui,Beihui Liu,James Hewinson,Hisashi Shirakawa,Takayuki Nakagawa,Hitoshi Hashimoto,Sergey Kasparov,Shuji Kaneko +16 more
TL;DR: It is demonstrated that acute activation of serotonergic neurons in the dorsal raphe nucleus increases active coping with inescapable stress in rats and mice in a time-locked manner, and that acute inhibition of these neurons increases anxiety-like behaviors specifically in rats.
Journal ArticleDOI
Prediction of pharmacological activities from chemical structures with graph convolutional neural networks.
Miyuki Sakai,Kazuki Nagayasu,Norihiro Shibui,Chihiro Andoh,Kaito Takayama,Hisashi Shirakawa,Shuji Kaneko +6 more
TL;DR: In this paper, a graph convolutional neural network (GCN) model was used to predict the activity of compounds from the ChEMBL database using two-dimensional structural information.
Journal ArticleDOI
Ketamine-Induced Prefrontal Serotonin Release Is Mediated by Cholinergic Neurons in the Pedunculopontine Tegmental Nucleus.
Haruko Kinoshita,Naoya Nishitani,Yuma Nagai,Chihiro Andoh,Nozomi Asaoka,Hiroyuki Kawai,Norihiro Shibui,Kazuki Nagayasu,Hisashi Shirakawa,Takayuki Nakagawa,Shuji Kaneko +10 more
TL;DR: The results suggest the ketamine-induced serotonin release in medial prefrontal cortex is mediated by cholinergic neurons projecting from pedunculopontine tegmental nucleus to dorsal raphe nucleus via α4β2 nAChRs.
Journal ArticleDOI
Chronic antidepressant potentiates spontaneous activity of dorsal raphe serotonergic neurons by decreasing GABAB receptor-mediated inhibition of L-type calcium channels.
Nozomi Asaoka,Naoya Nishitani,Haruko Kinoshita,Hiroyuki Kawai,Norihiro Shibui,Kazuki Nagayasu,Hisashi Shirakawa,Takayuki Nakagawa,Shuji Kaneko +8 more
TL;DR: Chronic administration of an antidepressant, citalopram, disinhibited the serotonergic spontaneous firing activity by weakening the GABAB receptor-mediated inhibition of L-type VDCCs in Serotonergic neurons.
Journal ArticleDOI
A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons.
Nozomi Asaoka,Hiroyuki Kawai,Naoya Nishitani,Haruko Kinoshita,Norihiro Shibui,Kazuki Nagayasu,Hisashi Shirakawa,Shuji Kaneko +7 more
TL;DR: The results suggest that 5F-ADB activates local CB1 receptors and potentiates midbrain dopaminergic systems with no direct effects on midbrain serotonergic systems.