Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats.
Naoya Nishitani,Kazuki Nagayasu,Kazuki Nagayasu,Nozomi Asaoka,Mayumi Yamashiro,Chihiro Andoh,Yuma Nagai,Haruko Kinoshita,Hiroyuki Kawai,Norihiro Shibui,Beihui Liu,James Hewinson,Hisashi Shirakawa,Takayuki Nakagawa,Hitoshi Hashimoto,Sergey Kasparov,Shuji Kaneko +16 more
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TLDR
It is demonstrated that acute activation of serotonergic neurons in the dorsal raphe nucleus increases active coping with inescapable stress in rats and mice in a time-locked manner, and that acute inhibition of these neurons increases anxiety-like behaviors specifically in rats.About:
This article is published in Neuropsychopharmacology.The article was published on 2019-03-01 and is currently open access. It has received 52 citations till now. The article focuses on the topics: Serotonergic & Dorsal raphe nucleus.read more
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Embracing diversity in the 5-HT neuronal system.
TL;DR: This Review discusses recent data from molecular genetic, genomic and functional methods that yield a reframing of the 5-HT neuronal system as a conglomeration of diverse subsystems with potential to inspire novel, more targeted therapies for clinically distinct 5- HT-related disorders.
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Optogenetic and chemogenetic insights into the neurocircuitry of depression-like behaviour: A systematic review.
Tom Biselli,Susen Sophie Lange,Lynn Sablottny,Johannes Steffen,Andreas Walther,Andreas Walther +5 more
TL;DR: A complex interacting network of relevant structures, in which central circuitries causally related to depressive‐like behaviour are implicated, has been identified and most relevant structures emerge: medial prefrontal cortex, anterior cingulate cortex, amygdala, nucleus accumbens, ventral tegmental area, hippocampus and raphe nuclei.
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Roles for androgens in mediating the sex differences of neuroendocrine and behavioral stress responses.
TL;DR: The role of androgens in stress-related behaviors and HPA function has been explored in this paper, focusing on androgens as an important hormone for modulating the HPA axis and behaviors throughout life and for setting up sex differences in key stress regulatory systems that could impact risk for disease in adulthood.
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Targeting Serotonin1A Receptors for Treating Chronic Pain and Depression.
TL;DR: This arti-cle targets the 5-HT1A receptors to show that indiscriminate activation of pre and postsynaptic 5- HT1A receptor receptors is likely to produce no therapeutic benefits; biased activation of the5-HT heteroreceptors may be a useful strategy for treating chronic pain and depression individually as well as in a comorbid condition.
Journal ArticleDOI
Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons
Chen Li,Fantao Meng,Jacob C. Garza,Jing Liu,Yun Lei,Sergei A. Kirov,Ming Guo,Ming Guo,Xin Yun Lu +8 more
TL;DR: It is shown that adiponectin receptor 1 (AdipoR1) is expressed in the dorsal raphe nucleus (DRN) and colocalized with tryptophan hydroxylase 2 (TPH2), a marker of serotonin (5-HT) neurons, and acts on 5-HT neurons through AdipOR1 receptors to regulate depression-related behaviors in a sex-dependent manner.
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