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Noriko Hotta-Hirashima
Researcher at University of Tsukuba
Publications - 12
Citations - 542
Noriko Hotta-Hirashima is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Sleep in non-human animals & Medicine. The author has an hindex of 6, co-authored 8 publications receiving 310 citations.
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Journal ArticleDOI
Forward-genetics analysis of sleep in randomly mutagenized mice
Hiromasa Funato,Hiromasa Funato,Chika Miyoshi,Tomoyuki Fujiyama,Takeshi Kanda,Makito Sato,Makito Sato,Zhiqiang Wang,Jing Ma,Shin Nakane,Jun Tomita,Aya Ikkyu,Miyo Kakizaki,Noriko Hotta-Hirashima,Satomi Kanno,Haruna Komiya,Fuyuki Asano,Takato Honda,Staci Jakyong Kim,Kanako Harano,Hiroki Muramoto,Toshiya Yonezawa,Seiya Mizuno,Shinichi Miyazaki,Linzi Connor,Vivek Kumar,Ikuo Miura,Tomohiro Suzuki,Atsushi Watanabe,Manabu Abe,Fumihiro Sugiyama,Satoru Takahashi,Kenji Sakimura,Yu Hayashi,Qinghua Liu,Kazuhiko Kume,Shigeharu Wakana,Joseph S. Takahashi,Masashi Yanagisawa +38 more
TL;DR: Two dominant mutations that affect sleep and wakefulness are identified by using an electroencephalogram/electromyogram-based screen of randomly mutagenized mice and the role of SIK3 and NALCN in regulating the amount of NREMS and REMS is demonstrated.
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Quantitative phosphoproteomic analysis of the molecular substrates of sleep need.
Zhiqiang Wang,Jing Ma,Chika Miyoshi,Yuxin Li,Makito Sato,Yukino Ogawa,Tingting Lou,Chengyuan Ma,Xue Gao,Chi-Yu Lee,Tomoyuki Fujiyama,Xiaojie Yang,Shuang Zhou,Noriko Hotta-Hirashima,Daniela Klewe-Nebenius,Aya Ikkyu,Miyo Kakizaki,Satomi Kanno,Liqin Cao,Satoru Takahashi,Junmin Peng,Yonghao Yu,Hiromasa Funato,Hiromasa Funato,Masashi Yanagisawa,Masashi Yanagisawa,Qinghua Liu +26 more
TL;DR: In this paper, the authors investigated the molecular basis of sleep need using quantitative phosphoproteomic analysis of the sleep-deprived and sleepy mouse models of increased sleep need.
Journal ArticleDOI
A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.
Takato Honda,Tomoyuki Fujiyama,Chika Miyoshi,Aya Ikkyu,Noriko Hotta-Hirashima,Satomi Kanno,Seiya Mizuno,Fumihiro Sugiyama,Satoru Takahashi,Hiromasa Funato,Hiromasa Funato,Masashiyanagisawa Yanagisawa +11 more
TL;DR: It is demonstrated that single amino acid changes at SIK3 S551 (S551A and S551D) reproduce the hypersomnia phenotype of the Sleepy mutant mice, suggesting that the evolutionally conserved S551 of Sik3 mediates the intracellular signaling crucial for the regulation of daily sleep amounts and sleep need at the organismal level.
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Gut microbiota depletion by chronic antibiotic treatment alters the sleep/wake architecture and sleep EEG power spectra in mice.
Yukino Ogawa,Yukino Ogawa,Yukino Ogawa,Chika Miyoshi,Nozomu Obana,Kaho Yajima,Noriko Hotta-Hirashima,Aya Ikkyu,Satomi Kanno,Tomoyoshi Soga,Shinji Fukuda,Masashi Yanagisawa +11 more
TL;DR: Sleep analysis based on electroencephalogram and electromyogram recordings revealed that AIMD mice spent significantly less time in non-rapid eye movement sleep (NREMS) during the light phase while spending more time in NREMS and rapid eye movementSleep (REMS), during the dark phase.
Journal ArticleDOI
Methodology and theoretical basis of forward genetic screening for sleep/wakefulness in mice
Chika Miyoshi,Staci Jakyong Kim,Takahiro Ezaki,Aya Ikkyu,Noriko Hotta-Hirashima,Satomi Kanno,Miyo Kakizaki,Mana Yamada,Shigeharu Wakana,Masashi Yanagisawa,Hiromasa Funato,Hiromasa Funato +11 more
TL;DR: A large-scale screening system using EEG/EMG-based sleep/wake monitoring with reliable parameters is established and the theoretical basis of forward genetics research for sleep in mice is discussed.