Takuya Yamashita

TL;DR: Comparison of inflammatory responses of various types of CNTs found that peritoneal CNT administration of long and thick MWCNTs increased the total cell number in abdominal lavage fluid in mice, suggesting DNA damage and severe inflammatory effects.

TL;DR: The results suggested that the well-dispersed amorphous nanosilica of particle size 70 nm (nSP70) penetrated the skin barrier and caused systemic exposure in mouse, and induced mutagenic activity in vitro, indicated that further studies of relation between physicochemical properties and biological responses are needed for the development and the safer form of NMs.

TL;DR: This review discusses currently available information regarding the safety of carbon nanomaterials in nanomedicine applications, including information obtained from the authors' own studies; and it discusses types of carbonnanommaterials that demonstrate particular promise for safe nanomedicsine technologies.

TL;DR: It is suggested that if interaction between n SP70 and coagulation factors can be suppressed, nSP70-induced harmful effects may be avoided and new frontiers in biological fields by the use of NMs are opened.

TL;DR: Results suggest that selective blocking of TNFR1 by PEG-R1antTNF could be an effective therapeutic strategy against MS.