N
Norman Chieng
Researcher at International Medical University
Publications - 12
Citations - 1031
Norman Chieng is an academic researcher from International Medical University. The author has contributed to research in topics: Amorphous solid & Crystallization. The author has an hindex of 9, co-authored 12 publications receiving 911 citations. Previous affiliations of Norman Chieng include University of Eastern Finland & University of Otago.
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An overview of recent studies on the analysis of pharmaceutical polymorphs.
TL;DR: The commonly used solid-state analytical techniques, the type of information collected, and advantages and disadvantages of each technique are discussed, with the focus on their application inSolid-state characterization and monitoring solid- state transformations, such as amorphization, crystallization, hydrate formation/dehydration and cocrystal formation.
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Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: Amorphous naproxen-cimetidine mixtures prepared by mechanical activation.
TL;DR: No recrystallization of either drug in the 1:1 co-milled sample was observed during dissolution testing, with naproxen and cimetidine having a four and two times higher intrinsic dissolution rate, respectively, compared to their crystalline counterparts.
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Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation.
TL;DR: Although XRPD, DSC and DRIFTS suggested an interaction between the two drugs, co-crystal formation was not observed between indomethacin and ranitidine hydrochloride.
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Formation Kinetics and Stability of Carbamazepine―Nicotinamide Cocrystals Prepared by Mechanical Activation
TL;DR: Co-milling of various CBZ polymorphic forms (form I, III and dihydate) with nicotinamide (NIC) was performed in this paper to investigate the formation kinetics of carbamazepine−nic...
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Effect of milling conditions on the solid-state conversion of ranitidine hydrochloride form 1
TL;DR: X-ray powder diffraction (XRPD), diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), solid-state nuclear magnetic resonance (NMR) and differential scanning calorimetry (DSC) were used to monitor solid- state properties of the milled samples.